5-Fluorocytosine
Supplier: ADIPOGEN CORP MS
Synonyms:
5-FC, 4-Amino-5-fluoro-2-pyrimidinol, Flucytosine, 6-Amino-5-fluoropyrimidin-2(1H)-one
Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.
Formula:
C₄H₄FN₃O MW: 129.09 g/mol |
MDL Number:
MFCD00006035 CAS Number: 2022-85-7 |
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