3-Cyanoumbelliferone

Supplier: ADIPOGEN CORP MS

Synonyms: 3-Cyano-7-hydroxycoumarin, 7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile

CDX-C0007-M100 CDX-C0007-G001 CDX-C0007-G005

102987-526EA 139.85 USD

102987-526 102987-528 102987-530

3-Cyanoumbelliferone

3-Cyanoumbelliferone

Phenolic dyes with high pKas - such as 7-hydroxycoumarin (often called umbelliferone) and the more common 7-hydroxy-4-methylcoumarin - are not fully deprotonated and therefore not fully fluorescent unless the pH of the reaction mixture is raised to above pH ~10. Thus, substrates derived from these fluorophores are seldom used for continuous measurement of enzymatic activity in solution or live cells. The similar 3-cyano-7-hydroxycoumarin and 6,8-difluoro-7-hydroxy-4-methylcoumarin have lower pKas, making them suitable for a broader range of applications. Moreover, the -trifluoromethylumbelliferone product has longer-wavelength spectra and stronger absorbance than -methylumbelliferone. Ether, ester and phosphate substrates derived from these phenolic dyes may be fluorescent but invariably exhibit shorter-wavelength absorption and emission spectra.

Formula: C₁₀H₅NO₃
MW: 187.15 g/mol

MDL Number: MFCD00037480
CAS Number: 19088-73-4

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