Verapamil hydrochloride USP

Supplier: ADIPOGEN CORP MS

Synonyms: 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile hydrochloride, Verapamil HCl, 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride, (±)-Verapamil hydrochloride

AG-CR1-3627-G005 AG-CR1-3627-M100 AG-CR1-3627-G001
102987-438EA 124.62 USD
102987-438 102988-818 102988-820
Verapamil hydrochloride USP
Verapamil hydrochloride

alpha1-Adrenergic receptor (alpha-AR) antagonist. Prototypical calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Vasodilator known to reduce the renal clearance of digoxin and used to control hypertension, angina, cardiac arrhythmia and vascular headaches. Apoptosis inducer in primary and metastatic colon adenocarcinoma human cell lines in vitro. Inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein) which are often over-expressed in certain tumor cell lines. Substrate of CYP3A4 and CYP2C6. Used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Anti-diabetic in animal models by limiting TXNIP expression.

Formula: C₂₇H₃₈N₂O₄
MW: 491.07 g/mol
MDL Number: MFCD00055208
CAS Number: 152-11-4

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