Glibenclamide USP
Supplier: ADIPOGEN CORP MS
Synonyms:
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulphamoyl)phenethyl)-2-methoxybenzamide, 5-Chloro-N-[4-(3-cyclohexylureidosulphonyl)phenethyl]-2-methoxybenzamide, Glyburide
Antidiabetic compound. Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1). Causes cell membrane depolarization and opening of voltage-dependent calcium channel. Increases intracellular calcium and stimulates insulin secretion in beta cells NLRP3 inflammasome inhibitor. Broad-spectrum ATP-binding cassette (ABC) transporter inhibitor. Shown to have anti-leishmanial activity. Potential inhibitor of collagenases.
Formula:
C₂₃H₂₈ClN₃O₅S MW: 494.00 g/mol |
MDL Number:
MFCD00056625 CAS Number: 10238-21-8 |
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