3-Methyladenine

Supplier: ADIPOGEN CORP MS

Synonyms: 3-Methyl-3H-purin-6-amine, 3-Methyl-3H-adenine

AG-CR1-3597-M025 AG-CR1-3597-M100 AG-CR1-3597-M250

102988-714EA 41.54 USD

102988-714 102988-716 102988-718

3-Methyladenine

3-Methyladenine

Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Blocks class I, class II and class III PI3Ks, including some downstream targets. Blocks class I PI3K persistently and class III PI3K transiently. Induces autophagy under nutrient-rich conditions and inhibits starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase. Shows some limited Vps34 preference in vitro compared to PtdIns3Kgamma. However, it is typically employed in cellular studies at a concentration of 10 mM, which can inhibit all PtdIns3Ks. Can target other kinases and affect other cellular processes, such as glycogen metabolism, lysosomal acidification, endocytosis and mitochondrial permeability transition. Anticancer compound. Neuroprotective. PKA-activation dependent lipolytic agent. Enhances ATGL-dependent hydrolysis of triacylglycerols.

Formula: C₆H₇N₅
MW: 149.16 g/mol

MDL Number: MFCD00010531
CAS Number: 5142-23-4

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