Necrostatin-1

Supplier: ADIPOGEN CORP MS

Synonyms: 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one, Nec-1

AG-CR1-2900-M005 AG-CR1-2900-M025
102988-560EA 48.46 USD
102988-560 102988-562
Necrostatin-1
Necrostatin-1

Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Cardioprotective and neuroprotective.

Formula: C₁₃H₁₃N₃OS
MW: 259.327 g/mol
MDL Number: MFCD00056916
CAS Number: 4311-88-0

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