(S)-(+)-Camptothecin ≥98% (by HPLC)
Supplier: ADIPOGEN CORP MS
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Danger
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Synonyms:
(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (+)-Camptothecin, 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Potent anticancer compound. Cell permeable potent DNA topoisomerase I (Topo I) complex inhibitor. Potent apoptosis inducer. Binds reversibly to the DNA topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, consequently depleting cellular topoisomerase I. Prevents DNA re-ligation and therefore causes DNA damage which results in apoptosis. Inhibits mitochondrial topoisomerase I (mtTop1). Blocks the cell cycle at low dose and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes. Antiprotozoal and antimalarial compound. Inhibitor of HIV replication and of other viruses. Suppresses nitric oxide (NO) biosynthesis. Shown to suppress TNF-alpha-induced expression of the inflammasome and cyclooxygenase 2 (COX-2).
Formula:
C₂₀H₁₆N₂O₄ MW: 348.36 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00081076 CAS Number: 7689-03-4 UN: 2811 ADR: 6.1,III |
Specification Test Results
Source/Host | Isolated from Camptotheca acuminata. |
Purity |
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Appearance/Color | White solid. |
Solubility | Soluble in DMSO, DMF or MeOH. Insoluble in water |
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