Cytosine-β-D-arabinofuranoside hydrochloride, Powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent. It results in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinofuranoside hydrochloride can function as a ligand which shows strong affinity and selectivity for the Translocator protein (TSPO). Studies suggest that Cytosine β-D-arabinofuranoside hydrochloride can down-regulate deoxycytidine kinase in acute myeloid leukemia murine cell lines which inhibits the phosphorylation of several deoxyribonucleosides. Furthermore, Cytosine β-D-arabinofuranoside hydrochloride can be inhibited in myeloid leukemic cells via suppression of ENT1 promoter activity, responsible for transporting Cytosine β-D-arabinofuranoside into the cell.
Cytosine β-D-arabinofuranoside hydrochloride is a selective inhibitor of DNA synthesis that does not affect RNA synthesis in mammalian cells. It is used as an antineoplastic and antiviral agent.
Soluble in water (50 mg/mL - clear, colorless solution).
Ara-C an anti-leukemia agent is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. It does not inhibit RNA synthesis.
Formula:
C₉H₁₄ClN₃O₅ |
MDL Number:
MFCD00012839 CAS Number: 69-74-9 |
Specification Test Results
Form | White Powder |
Storage | Store at 2-8 °C. |
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