Geldanamycin (from Streptomyces hygroscopicus) ≥98% (by HPLC)
Supplier: ADIPOGEN CORP MS
Synonyms:
(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Geldanamycin is a potent nuclear hormone receptor family inhibitor.
- Antibiotic
- Inhibits c-mycgene expression in murine lymphoblastoma cells
- Potent antitumor compound
Antibiotic. pp60src tyrosine kinase inhibitor. Inhibits the transforming activity of abl, erbB, fps, src and yes. Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Destabilizes several oncogene and proto-oncogene products.
Solid
After reconstitution protect from light at -20°C. Stable for at least one year after receipt when stored at -20°C.
Colour: Yellow
Formula:
C₂₉H₄₀N₂O₉ MW: 560.64 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00274570 CAS Number: 30562-34-6 |
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