Tacrolimus monohydrate ≥98%
Supplier: ADIPOGEN CORP MS
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Danger
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Synonyms:
FK 506, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate
Potent immunosuppressant (as cyclosporin A and rapamycin). Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Forms a complex with FK-506 binding protein 12 (FKBP12). Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin), leading to disruption of T cell activation. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2+ release compound. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis inducer.
Formula:
C₄₄H₇₁NO₁₃ MW: 822.03 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD11045918 CAS Number: 109581-93-3 UN: 2811 ADR: 6.1,III |
Specification Test Results
Source/Host | Isolated from Streptomyces FCZ0311. |
Purity | >98% |
Appearance/Color | White to off-white solid. |
Solubility | Soluble in DMSO, ethanol, methanol, ethyl acetate or acetone. Insoluble in water. |
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