Tacrolimus monohydrate ≥98%

Supplier: ADIPOGEN CORP MS
Danger

Synonyms: FK 506, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate

AG-CN2-0047-M001 AG-CN2-0047-M005 AG-CN2-0047-M025
102515-844EA 20.77 USD
102515-844 102515-846 102515-848
Tacrolimus monohydrate ≥98%
Tacrolimus monohydrate

Potent immunosuppressant (as cyclosporin A and rapamycin). Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Forms a complex with FK-506 binding protein 12 (FKBP12). Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin), leading to disruption of T cell activation. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2+ release compound. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis inducer.

Formula: C₄₄H₇₁NO₁₃
MW: 822.03 g/mol
Storage Temperature: Freezer
MDL Number: MFCD11045918
CAS Number: 109581-93-3
UN: 2811
ADR: 6.1,III

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Specification Test Results

Source/Host Isolated from Streptomyces FCZ0311.
Purity >98%
Appearance/Color White to off-white solid.
Solubility Soluble in DMSO, ethanol, methanol, ethyl acetate or acetone. Insoluble in water.

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