Etoposide ≥98% (by HPLC)
Supplier: ADIPOGEN CORP MS
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Danger
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Synonyms:
(5R,5aR,8aR,9S)-9-(((4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one, 4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-beta-D-glucopyranoside)
Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication. p53 activator. Blocks the cell cycle between the end of the S phase and the early G2 phase. Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcription and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation. Highly effective in mobilizing stem cells
Formula:
C₂₉H₃₂O₁₃ MW: 588.56 g/mol Storage Temperature: Ambient |
MDL Number:
MFCD00869325 CAS Number: 33419-42-0 |
Specification Test Results
Source/Host | Semisynthetic derivative of podophyllotoxin. |
Purity |
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Appearance/Color | White to off-white powder. |
Solubility | Soluble in DMSO, ethanol, methanol or dimethylformamide. |
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