Colchicine

Supplier: ADIPOGEN CORP MS
Danger

Synonyms: 7α-H-Colchicine, (S)-(-)-Colchicine

AG-CN2-0048-M500 AG-CN2-0048-G001
102515-850EA 96.92 USD
102515-850 102515-852
Colchicine
Colchicine

Anti-cancer compound. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Anti-inflammatory compound. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behect's disease. Investigated for its anti-cancer activity. It has a narrow therapeutic index with no clear-cut distinction between nontoxic, toxic and lethal doses, causing substantial confusion among clinicians. Apoptosis inducer in a variety of normal and tumor cell lines. Inhibitor of autophagosome-lysosome fusion. Inhibits acetylated a-tubulin mediated dynein dependent transport of mitochondria and subsequent apposition of ASC on mitochondria to NLRP3 on the endoplasmic reticulum in vitro and in vivo.

Formula: C₂₂H₂₅NO₆
MW: 399.44 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00078484
CAS Number: 64-86-8
UN: 3462
ADR: 6.1,III

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Specification Test Results

Source/Host Isolated from Colchicum autumnale.
Purity >98% (HPLC)
Appearance/Color White to off-white powder.
Solubility Soluble in 100% ethanol (>100mg/ml), DMSO (>100mg/ml), water or DMF.

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