Colchicine
Supplier: ADIPOGEN CORP MS
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Danger
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Synonyms:
7α-H-Colchicine, (S)-(-)-Colchicine
Anti-cancer compound. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Anti-inflammatory compound. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behect's disease. Investigated for its anti-cancer activity. It has a narrow therapeutic index with no clear-cut distinction between nontoxic, toxic and lethal doses, causing substantial confusion among clinicians. Apoptosis inducer in a variety of normal and tumor cell lines. Inhibitor of autophagosome-lysosome fusion. Inhibits acetylated a-tubulin mediated dynein dependent transport of mitochondria and subsequent apposition of ASC on mitochondria to NLRP3 on the endoplasmic reticulum in vitro and in vivo.
Formula:
C₂₂H₂₅NO₆ MW: 399.44 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00078484 CAS Number: 64-86-8 UN: 3462 ADR: 6.1,III |
Specification Test Results
Source/Host | Isolated from Colchicum autumnale. |
Purity | >98% (HPLC) |
Appearance/Color | White to off-white powder. |
Solubility | Soluble in 100% ethanol (>100mg/ml), DMSO (>100mg/ml), water or DMF. |
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