Cyclopamine ≥98%
Supplier: ADIPOGEN CORP MS
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Warning
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Synonyms:
(2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11,11a,11b-octadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-3-ol
Cell permeable steroidal alkaloid. Specific sonic hedgehog (Shh) signaling pathway inhibitor. Directly interacts/inhibits Smo (smoothened). Teratogenic and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against Shh-dependent tumors. Blocks abnormal cell growth associated with oncogenic mutations of Ptch and Smo in fibroblasts. Arrests cell cycle at G0/G1. Apoptosis inducer.
Formula:
C₂₇H₄₁NO₂ MW: 411.63 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD09878269 CAS Number: 4449-51-8 |
Specification Test Results
Source/Host | Isolated from Veratrum californicum. |
Purity |
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Appearance/Color | White to off-white solid. |
Solubility | Soluble in ethanol, methanol, DMF or DMSO. Insoluble in water. |
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