Splitomicin ≥98% (by NMR)
Supplier: ADIPOGEN CORP MS
Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.
Formula:
C₁₃H₁₀O₂ Storage Temperature: Freezer |
MDL Number:
MFCD08705254 CAS Number: 5690-03-9 |
Specification Test Results
Purity |
|
Appearance/Color | White to off-white solid. |
Solubility | Soluble in methanol, ethanol or DMSO. |
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