PD 184,352 ≥95% (by HPLC, total nitrogen)

Supplier: ADIPOGEN CORP MS
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Synonyms: 2-(2-Chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide, 2-((2-Chloro-4-iodophenyl)amino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide, PD 184352, CI-1040

AG-CR1-0029-M001 AG-CR1-0029-M005
102515-984EA 27.69 USD
102515-984 102515-986
PD 184,352 ≥95% (by HPLC, total nitrogen)
PD 184,352

MEK (MAPKK) inhibitor. Potent and selective MAPK (ERK kinase 1; MEK1) activation inhibitor (IC50 = 300 nM in vitro, IC50 = 2 nM in vivo). Suppresses activation of MAPK but does not block its activity. Antiproliferative. Causes cell-cycle arrest in G1 phase. Tumor suppressor. Apoptosis inducer.

Formula: C₁₇H₁₄ClF₂IN₂O₂
MW: 478.7 g/mol
Storage Temperature: Freezer
MDL Number: MFCD02683961
CAS Number: 212631-79-3

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Specification Test Results

Purity 95% (HPLC, NMR)
Appearance/Color White to off-white solid.
Solubility Soluble in DMSO.

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