DAPT ≥98% (by NMR)

Supplier: ADIPOGEN CORP MS

Synonyms: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate, (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu, (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester

AG-CR1-0016-M005 AG-CR1-0016-M025
102515-918EA 90 USD
102515-918 102515-920
DAPT ≥98% (by NMR)
DAPT

Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis enhancer.

Formula: C₂₃H₂₆F₂N₂O₄
MW: 432.47 g/mol
Storage Temperature: Freezer
MDL Number: MFCD04974585
CAS Number: 208255-80-5

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Specification Test Results

Purity 98% (NMR)
Appearance/Color White to off-white solid.
Solubility Soluble in 100% ethanol, DMSO (20 mg/ml) or dichloromethane.

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