DAPT ≥98% (by NMR)
Supplier: ADIPOGEN CORP MS
Synonyms:
N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate, (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu, (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester
Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis enhancer.
Formula:
C₂₃H₂₆F₂N₂O₄ MW: 432.47 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD04974585 CAS Number: 208255-80-5 |
Specification Test Results
Purity |
|
Appearance/Color | White to off-white solid. |
Solubility | Soluble in 100% ethanol, DMSO (20 mg/ml) or dichloromethane. |
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