(R)-Roscovitine ≥98% (by NMR)
Supplier: ADIPOGEN CORP MS
Synonyms:
2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Roscovitine, (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM), CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 = 160 nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways[10]. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews.
Formula:
C₁₉H₂₆N₆O MW: 354.45 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD02266401 CAS Number: 186692-46-6 |
Specification Test Results
Purity | >98% (NMR) |
Appearance/Color | White to off-white solid. |
Solubility | Soluble in DMSO or 100% ethanol; only moderately soluble in water. |
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