Wortmannin (from Penicillium species) ≥98% (by HPLC)
Supplier: ADIPOGEN CORP MS
Synonyms:
(1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
Wortmannin is a potent anti-neutrophil agent with cardioprotective effects.
- Cell permeable and selective inhibitor
- More suitable inhibitor than 3-MA
- TRAIL sensitizer
Antibiotic. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Similar potency in vitro for the class I, II, and III PI3K. Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor, regardless of the nutrient status and thus is a more suitable autophagy inhibitor than 3-MA. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor.
White to off-white solid
Stable for at least 2 years after receipt when stored at -20°C.
Soluble in DMSO methanol, ethanol or chloroform. Slightly soluble in water.
Formula:
C₂₃H₂₄O₈ MW: 428.44 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00133927 CAS Number: 19545-26-7 |
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