Nigericin sodium salt ≥98% (by TLC)
Supplier: ADIPOGEN CORP MS
Synonyms:
Sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-3-methyltetrahydro-2H-pyran-2-yl)propanoate
Nigericin is a high-affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+.
- Disrupts mebrane potential of mitochondria
- Autophagy modulator
- High-affinity ionophore
Antibiotic. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator.
White to off-white powder
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Soluble in methanol, ethanol, dichlormethane or ethyl acetate. Insoluble in water.
Formula:
C₄₀H₆₇NaO₁₁ MW: 746.94 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00036825 CAS Number: 28643-80-3 |
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