TDO (from Escherichia coli), AdipoGen Life Sciences

Supplier: ADIPOGEN CORP MS

AG-40T-0101-C050
102980-438EA 540 USD
102980-438
TDO (from Escherichia coli), AdipoGen Life Sciences
Enzymes

Tryptophan 2,3-dioxygenase (TDO) is a heme-containing dioxygenase catalyzing the addition of molecular oxygen across the 2,3-double bond of the indole ring of tryptophan to form N-formylkynurenine (NFK)


  • UniProt link O77457: TDO (Anopheles gambiae)


In Anopheles gambiae, TDO is the only enzyme able to catalyze the first and rate-limiting step in L-Trp catabolism through the kynurenine pathway. Tryptophan is an essential amino acid for protein synthesis and also the precursor for production of a number of neurotransmitters, such as serotonin and melatonin; in mosquitoes, the kynurenine pathway is essential for eye pigmentation. Conceivably, the tryptophan-using pathways should be regulated in a coordinated manner in mosquitoes as well as in other species and TDO activation/inactivation processes could play an essential role in these phenomena.

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