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Description: VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.
Catalog Number: 75933-584
Supplier: Rockland Immunochemical


Description: Roller Bottles are optimal vessels for a large yield of cell growth and multiplication, to be used in both research and manufacturing applications.
Catalog Number: 76271-456
Supplier: VWR International



Description: VWR® tube rollers are designed for gentle yet complete mixing of a wide range of sample vessels and tubes.
Catalog Number: 76637-522
Supplier: VWR International


Description: Efficient and practical solution for tube roller workflows.
Catalog Number: 77531-578
Supplier: VWR International

New Product


Description: This 10.2 cm (4") soft rubber roller is designed for assuring tight and consistent application of adhesive films and foils to microplates.
Catalog Number: 60941-118
Supplier: VWR International

Description: VWR* Roller Base for DH models: with 2 locking casters, 2 leveling feet, 23/4 in, Roller Dolly (heavy-duty, powder coated steel base) with dual-wheel, swivel locking casters and levelling feet, supports one or two (stacked) incubators, raises unit 3.0in (7.6cm) off the floor
Catalog Number: 10820-346
Supplier: VWR International


Description: Unit is designed to measure centrifuges, pumps, rollers, shafts, gears, motors, and moving surfaces.
Catalog Number: 46610-046
Supplier: VWR International


Description: Storage: Store at -20 °C.
Brefeldin A is a fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. Produced by Penicillium brefeldianum. Blocks binding of the cytosolic coat protein b-COP and ARF to Golgi membranes mediated by protein G. Also blocks protein transportation into post-Golgi compartments. It activates the sphingomyelin cycle. Brefeldin A mediated apoptosis has been observed in human tumor cells.
Brefeldin A reversibly inhibits the intracellular translocation of proteins in eukaryotes, e.g., during transport of proteins to the cell surface for secretion or expression. It has been reported to block the response of cultured cells to cholera toxin. In HepG2 cells, BFA induces two blocks in the secretory pathway; one at the level of the endoplasmic reticulum-Golgi juncture and the other in the trans-Golgi network. Brefeldin A is used in the studies of Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Catalog Number: 76177-788
Supplier: MP Biomedicals


Description: An easy alternative to rollers, these plate paddles are designed to provide secure sealing around all wells on a microplate.
Catalog Number: 60941-128
Supplier: VWR International

Description: BTXpress Cytoporation® Media T/T4 is an advanced electroporation buffer designed for use with the BTX AgilePulse MAX™ large volume electroporation system for <i>in vitro</i> delivery of DNA, RNA, oligonucleotides, and siRNA. The low conductivity buffer is specially formulated to minimise heating of solution during large volume electroporation for maximum transfection efficiency and high cell viability. BTXpress Cytoporation® Media T and T4 are sterile filtered from the highest quality non animal, medical grade reagents. Buffer can be directly diluted in complete growth media for post electroporation cell culture.
Catalog Number: 77552-850
Supplier: Harvard Apparatus

New Product


Description: Accessories for VWR® Premium CO₂ Incubators
Catalog Number: 77581-136
Supplier: VWR International

New Product


Description: This two-line labeling gun features an ergonomic handle, reinforced ABS body with steel internal components, easy drop-in label loading, a simple snap-in/pop-out ink roller, and a self-align feed mechanism that provides jam-resistant operation.
Catalog Number: 10123-976
Supplier: VWR International


Description: Combine the accuracy of Ismatec® with the versatility of Masterflex® tubing pump systems.
Catalog Number: MFLX07623-00
Supplier: Avantor Fluid Handling

CE Compliant


Description: Ideal for high-purity fluids and aggressive organic solvents.
Catalog Number: MFLX77390-00
Supplier: Avantor Fluid Handling

1 year warranty ISO9000


Description: PYREX®, borosilicate glass.
Catalog Number: 22877-218
Supplier: Corning

Environmentally Preferable


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