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Catalog Number: (76545-462)
Supplier: Biosensis
Description: Mouse anti-beta-synuclein monoclonal antibody (unconjugated), suitable for WB, IHC-frozen.


Catalog Number: (76545-466)
Supplier: Biosensis
Description: Rabbit anti-pan-synuclein polyclonal antibody (unconjugated), suitable for WB, FC.


Catalog Number: (76545-480)
Supplier: Biosensis
Description: Rabbit anti-neuronal nuclei antigen/Fox3 (NeuN/Fox3) polyclonal antibody (unconjugated), suitable for WB, IHC, ICC.


Catalog Number: (76334-000)
Supplier: Biosensis
Description: Lamin A/C Monoclonal antibody, Clone: 4C4, Host: mouse, Reactivity: Human, Isotype: IgG1, Immunogen: Full length recombinant human Lamin C, Applications: WB, ICC, Flow, Form: Lyophilized from PBS. Contains 5% treh


Catalog Number: (76334-006)
Supplier: Biosensis
Description: Aldolase C Monoclonal antibody, Clone: 4A9, Host: mouse, Reactivity: Human, rat, mouse, cow, pig, Isotype: IgG1, Immunogen: N-terminal 20 amino acids of aldolase C protein, Applications: WB, ICC, Flow, Form: Lyophi


Catalog Number: (76334-038)
Supplier: Biosensis
Description: CNP antibody, Host: Rabbit, Reacts with human, rat, mouse, Purity: affinity purified, Antigen: Full-length recombinant human protein, Synonyms: CNP; CNPase, Applications: WB, ICC, IHC, Storage: Store lyophilised an


Catalog Number: (76334-016)
Supplier: Biosensis
Description: CNP Monoclonal antibody, Clone: 1H10, Host: Mouse, Reacts with human, rat, mouse, Purity: affinity purified, Antigen: Full-length recombinant human protein, Synonyms: CNP; CNPase, Applications: WB, ICC, IHC, Stora


Catalog Number: (76333-976)
Supplier: Biosensis
Description: CNP antibody, Host: Chicken, Reacts with human, rat, mouse, Purity: IgY fraction, Antigen: Full-length recombinant human protein, Synonyms: CNP; CNPase, Applications: WB, ICC, IHC, Storage: Store lyophilised antibo


Catalog Number: (76334-018)
Supplier: Biosensis
Description: Ki-67 Monoclonal antibody, Clone: 6B4, Host: Mouse, Reacts with human, Immunogen: Recombinant human Ki-67 protein (amino acids 1,111-1,490) expressed in and purified from E. Coli, Synonyms: Antigen KI-67; Antigen K


Catalog Number: (76265-480)
Supplier: Biosensis
Description: The capsaicin receptor (VR1, TRPV1) is a ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. The receptor seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. It is involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH less than 6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (Ref: uniprot.org). Antibody is specific for rat/mouse VR1 protein in westerns and immunofluorescent immunohistochemistry on mouse PEG fixed DRG tissues. Pre-absorption with immunogen obliterates positive staining. Cross reactivity with other non-VR1 proteins is minimal; cross reactivity with VR1 from other species not yet tested.


Catalog Number: (76333-984)
Supplier: Biosensis
Description: Neurotrophin Antibody Kit (Trial Size) contains 100 ug each of popular sheep antibodies raised against BDNF, NGF, NT3 and NT4/5, and a negative control sheep IgG, to investigate neurotrophin protein expression and


Catalog Number: (76333-980)
Supplier: Biosensis
Description: Nestin antibody, Host: Chicken, Reacts with human and rat, Purity: IgY fraction, Antigen: Part of recombinant human protein (amino acids 315-630), Applications: WB, ICC, Storage: Store lyophilised antibody at 2-8C


Catalog Number: (76333-996)
Supplier: Biosensis
Description: Ubiquilin 2 Monoclonal antibody, Clone: 6H9, Host: mouse, Reactivity: human and mouse, Isotype: IgG1, Immunogen: Recombinant human ubiquilin 2 expressed and purified from E. Coli, Applications: WB, ICC, Form: Lyophi


Catalog Number: (76334-040)
Supplier: Biosensis
Description: Ki-67 antibody, Host: Rabbit, Reacts with human, Purity: Whole serum, Antigen: Recombinant human Ki-67 protein (amino acids 1,111-1,490) expressed in and purified from E. Coli, Synonyms: Antigen KI-67, Applications


Catalog Number: (76264-900)
Supplier: Biosensis
Description: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. MMP2 isoform 2 mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. Catalytic activity of MMP2 causes cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. (Ref: uniprot.org). Antibody reacts with human. Expected to react with horse, cow, pig, chicken, rat and mouse MMP2.


Catalog Number: (10782-374)
Supplier: Biosensis
Description: BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post Translation Modification (PTM): The propeptide is N-glycosylated and glycosulfated. PTM: Converted into mature BDNF by plasmin (PLG) (By similarity). DISEASE: Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. SIMILARITY: Belongs to the NGF-beta family.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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