You Searched For: ADIPOGEN CORP MS

Catalog Number: (102512-040)

Supplier: Adipogen

Description: Human CD13 is a zinc-binding aminopeptidase-N enzyme expressed on the surface of myeloid cells. IL-4 will upregulate expression of CD13 which may play an anti-inflammatory role.

Catalog Number: (102512-086)

Supplier: Adipogen

Description: Human CD18 (beta integrin) forms a heterodimer with either alphaL, alphaM, or alphaX integrins (CD11a, b or c). CD11/CD18 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses.

Catalog Number: (102512-076)

Supplier: Adipogen

Description: Antibodies to human CD17 react with lactosylceramide which is expressed on granulocytes, monocytes, platelets and basophils. CD17 expression is downmodulated on activated granulocytes. CD17 is an important component in CD11b/CD18 mediated phagocytosis of microbes.

Catalog Number: (102512-096)

Supplier: Adipogen

Description: Human CD19 is a B cell restricted membrane protein expressed from early stages of B cell development and associates with the antigen receptor complex. CD19 is involved in the regulation of B cell proliferation.

Catalog Number: (102512-070)

Supplier: Adipogen

Description: Human CD16 is a low affinity receptor for complexed IgG and occurs in two distinct forms, as a glycosyl phosphatidyl inositol (GPI) anchored protein in granulocytes and as an integral membrane protein on NK cells and macrophages.

Catalog Number: (102512-050)

Supplier: Adipogen

Description: Human CD14 is strongly expressed on myelomonocyte lineage cells including monocytes, macrophages and a subset of granulocytes. CD14 is a high affinity receptor for complexes of lipopolysaccharide and lipopolysaccharide binding protein. A soluble form of CD14 also binds to LPS and LBP.

Catalog Number: (102512-120)

Supplier: Adipogen

Description: Human CD21 is a receptor for complement fragments C3d, C3dg or ic3D and also EBV. CD21 is also a ligand for CD23 and plays a role in IgE synthesis.

Catalog Number: (102512-124)

Supplier: Adipogen

Description: Human CD21 is a receptor for complement fragments C3d, C3dg or ic3D and also EBV. CD21 is also a ligand for CD23 and plays a role in IgE synthesis.

Catalog Number: (102514-374)

Supplier: Adipogen

Description: ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.

Catalog Number: (102514-402)

Supplier: Adipogen

Description: RELM-alpha is a member to the family of adipocyte-secreted proteins called adipocytokines. It is abundantly expressed in white adipose tissue but not in preadipocytes, nor 3T3-L1 adipocytes. RELM-alpha is involved in the regulation of colonic inflammation and might be a link between colonic injury, glucose tolerance, and energy intake.

Catalog Number: (102514-414)

Supplier: Adipogen

Description: The adipocytokine resistin which belongs to a family of cysteine-rich C-terminal proteins known as resistin-like molecules (RELM; RELMalpha/FIZZ 1 and RELMbeta/FIZZ 2) of FIZZ (found in inflammatory zone) are thought to be involved in inflammatory processes. Previous studies in mice showed that resistin impairs glucose tolerance and insulin action. In addition, resistin also inhibits adipogenesis in murine 3T3-L1 cells. Therefore resistin has also been proposed as an adipocyte-secreted factor thought to link obesity and T2DM.

Catalog Number: (102514-422)

Supplier: Adipogen

Description: The adipocytokine resistin which belongs to a family of cysteine-rich C-terminal proteins known as resistin-like molecules (RELM; RELMalpha/FIZZ 1 and RELMbeta/FIZZ 2) of FIZZ (found in inflammatory zone) are thought to be involved in inflammatory processes. Previous studies in mice showed that resistin impairs glucose tolerance and insulin action. In addition, resistin also inhibits adipogenesis in murine 3T3-L1 cells. Therefore resistin has also been proposed as an adipocyte-secreted factor thought to link obesity and T2DM.

Catalog Number: (102514-334)

Supplier: Adipogen

Description: Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF-R signaling is essential for B cell development, survival and humoral immune responses.

Catalog Number: (102514-686)

Supplier: Adipogen

Description: Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. Mouse IGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNFR family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

Catalog Number: (102514-672)

Supplier: Adipogen

Description: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

Catalog Number: (102514-628)

Supplier: Adipogen

Description: CTRP9 belongs to a highly conserved family of adiponectin paralogs. It activates AMPK, AKT and p44/42 MAPK signaling pathways. Expressed predominantly in adipose tissue. Females express higher levels than males. Overexpression of CTRP9 in obese (ob/ob) mice significantly lowered serum glucose levels.