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Annexin V Binding Buffer

Catalog Number: (MSPP-100-0334)

Supplier: STEMCELL Technologies

Description: Assay buffer for labeling with Annexin V - 50 ml.

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STEMdiff™ Cardiomyocyte Expansion Kit

Catalog Number: (MSPP-100-1109)

Supplier: STEMCELL Technologies

Description: A serum-free media kit for the expansion of early-stage human pluripotent stem cell-derived cardiomyocytes.

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EasySep™ Mouse PE Positive Selection Kit II

Catalog Number: (MSPP-17666)

Supplier: STEMCELL Technologies

Description: Immunomagnetic positive selection of mouse cells labeled with PE-conjugated antibodies.

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L-Glutamine

Catalog Number: (MSPP-07100)

Supplier: STEMCELL Technologies

Description: Cell culture supplement. 1×3 ml vial.

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Description: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).

Dispase, ACF

Catalog Number: (MSPP-100-0396)

Supplier: STEMCELL Technologies

Description: Animal component-free non-specific protease.

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Human Recombinant IL-4

Catalog Number: (MSPP-78045)

Supplier: STEMCELL Technologies

Description: Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant et al.). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms et al.). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into Th2 cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao et al.; Nelms et al.; Olpihant et al.). In addition to Th2 cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. Human IL-4 does not cross-react with mouse cells (Park et al.).