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Image Unavailable-10325-092

Anti-ADAR Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10325-092)
Supplier: Bioss
Description: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence.
Image Unavailable-10325-090

Anti-ADAR Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10325-090)
Supplier: Bioss
Description: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence.
Product Image-99901-386

AdEasy Virus Purification Kit, Agilent Technologies

Catalog Number: (99901-386)
Supplier: Agilent Technologies
Description: The AdEasy Virus Purification Kit allows the purification and concentration of Adenovirus (from Ad5 strains) with Sartobind® syringe filters containing an ion exchange membrane adsorber that selectively binds adenoviral particles. Once bound, viral particles can be further purified by washing away nonspecifically-bound proteins before elution. Concentrated and purified viral particles can be obtained in 2 to 3 hours, in contrast to traditional CsCl gradient centrifugation which typically takes 12 to 48 hours.
Product Image-75784-584

FastRNA™, Spin Kit, MP Biomedicals

Catalog Number: (75784-584)
Supplier: MP Biomedicals
Description: The FastRNA™ Spin Kit isolates both large and small RNA species without the use of phenol or reducing agents.

SDS


Product Image-76020-446

Quick-RNA™ Fungal/Bacterial Kits, Zymo Research

Supplier: Zymo Research
Description: Rapid isolation of total RNA from pelleted tough-to-lyse bacteria, yeast, and/or fungal cells.

Product Image-PAMB1004

MagaZorb DNA Mini-Prep Kit, Promega

Supplier: Promega Corporation
Description: The MagaZorb DNA Kit provides an easy, fast and cost-effective technique for isolating PCR-quality DNA.

Product Image-76020-590

Zymoclean™, Gel RNA Recovery Kit, Zymo Research

Catalog Number: (76020-590)
Supplier: Zymo Research
Description: The Zymoclean™ Gel RNA Recovery Kit provides a quick purification method for recovery of RNA fragments from agarose gels.
Image Unavailable-95043-224

Accessories for E.Z.N.A.® Tissue DNA Extraction Systems, Omega Bio-Tek

Supplier: Omega Bio-Tek
Description: 100ml.

Minority or Woman-Owned Business Enterprise

Product Image-76004-158

Zymo-Spin™ Column/Filter Assemblies, Zymo Research

Supplier: Zymo Research
Description: Columns and filters for the purification of DNA and/or RNA from high-volume sample inputs.

Product Image-PAE3310

QuantiFluor RNA System, 1ml, Promega

Catalog Number: (PAE3310)
Supplier: Promega Corporation
Description: The QuantiFluor RNA System contains a fluorescent RNA-binding dye that enables sensitive quantitation of small amounts of RNA in solution.

SDS Certificates


Image Unavailable-76098-706

Anti-ADAR1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76098-706)
Supplier: Bioss
Description: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence.
Image Unavailable-76194-040

Anti-TARBP2 Rabbit Polyclonal Antibody

Catalog Number: (76194-040)
Supplier: Prosci
Description: TRBP2 (TAR (HIV-1) RNA binding protein 2) , along with Dicer and Argonaute-2, is part of the RISC (RNA induced silencing complex). As part of the RISC, TRBP2 is important in viral defense. Dicer cleaves dsRNA into siRNA. Through TRBP2-Dicer interaction, the siRNA template is loaded onto Argonaute-2, which cleaves encountered viral mRNA strands complementary to the loaded siRNA base-pair sequence.
Product Image-76005-144

Zymo-Spin™ IC-XL Columns, Zymo Research

Supplier: Zymo Research
Description: Spin columns for the purification of DNA or RNA.

Product Image-95017-499

RNA isolation, illustra™ RNAspin 96 Kit, Cytiva

Catalog Number: (95017-499)
Supplier: Cytiva
Description: illustra™ RNAspin 96 kit is a flexible, high-throughput solution for total RNA isolation.

SDS Product available on GSA Advantage®


Product Image-103218-904

Epimark N6-Methyladenosine Enrichment Kit, New England Biolabs

Catalog Number: (103218-904)
Supplier: New England Biolabs (NEB)
Description: The EpiMark N6-Methyladenosine Enrichment Kit contains a rabbit monoclonal antibody specific for N6-Methyladenosine (m6A).

Small Business Enterprise


Product Image-76006-524

Tri-Isolate RNA Pure Kit, IBI Scientific

Supplier: IBI Scientific
Description: Cost-effective phenol, guanidine isothiocyanate plus spin column system for purification of high-quality total RNA.
Applications: cDNA Library Construction, Cloning, RT-PCR (Endpoint), Real-Time PCR, Nuclease Protection Assays, Northern Blotting

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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