You Searched For: traf6


487  results were found

SearchResultCount:"487"

Sort Results

List View Easy View

Rate These Search Results

Catalog Number: (102152-846)
Supplier: Novus Biologicals
Description: TRAF6 Overexpression Lysate (Adult Normal)


Catalog Number: (103484-036)
Supplier: Affymetrix, Inc.
Description: Suggested positive control: human thymus, testis cell lysate, antigen standard for TRAF6 (transient overexpression lysate). Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). Recently it has been shown that TRANCE/OPGL activates the antiapoptotic serine/threonine kinase Akt/PKB through a signaling complex involving c-Src and TRAF6 (5). Mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function (6). Like TRAF2 and TRAF3, TRAF6 is also essential for perinatal and postnatal survival. These findings establish unexpectedly diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling. RANK (TRANCE receptor) interacts with various TRAFs through distinct motifs and activates NF-kB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kB activation (7). Over-expression of TRAF6 activates JNK, p38, or IKK in the absence of extracellular stimulation.

Blocked

Supplier: AFG BIOSCIENCE LLC
Description: Anti-TRAF6 Rabbit Polyclonal Antibody

New Product

Catalog Number: (89357-286)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to TRAF6 (TNF receptor-associated factor 6)


Catalog Number: (76867-056)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit polyclonal antibody to TRAF6 for ICC/IF with samples derived from Human.


Catalog Number: (103592-018)
Supplier: Sino Biological
Description: Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human TRAF6, and purified by antigen affinity chromatography.


Catalog Number: (10543-632)
Supplier: Abnova
Description: This Set comes with matched Antibody Pair to detect and quantify protein level of human TRAF6.


Catalog Number: (76578-668)
Supplier: AFG BIOSCIENCE LLC
Description: Bovine TNF Receptor-associated Factor 6 (TRAF6) ELISA Kit, AFG Bioscience


Catalog Number: (10749-546)
Supplier: Prosci
Description: TRAF6 Antibody: Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kappa B. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.


Catalog Number: (76735-296)
Supplier: ANTIBODIES.COM LLC
Description: Human TRAF6 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human TRAF6 in serum, plasma, tissue homogenates, and other biological fluids.


Catalog Number: (102152-844)
Supplier: Novus Biologicals
Description: TRAF6 Overexpression Lysate (Adult Normal)


Catalog Number: (220011-023)
Supplier: R&D Systems
Description: Anti-TRAF6 Goat Polyclonal Antibody


Catalog Number: (89415-580)
Supplier: Prosci
Description: TRAF6 Antibody: Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kappa B. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.


Catalog Number: (10625-468)
Supplier: Abnova
Description: Mouse monoclonal antibody raised against a partial recombinant TRAF6.


Catalog Number: (102211-108)
Supplier: Novus Biologicals
Description: TRAF6 Peptide. Tested Applications: Blocking/Neutralizing. Tested Reactivity: Human.


Catalog Number: (MSPP-PAG751HU1)
Supplier: CLOUD-CLONE CORP MS
Description: Polyclonal Antibody to TNF Receptor Associated Factor 6 (TRAF6), derived from recombinant TRAF6 (Ala153~Pro423), is reactive with Human/Mouse.

New Product


Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
1 - 16 of 487
no targeter for Bottom