You Searched For: traf2


441  results were found

SearchResultCount:"441"

Sort Results

List View Easy View

Rate These Search Results

Catalog Number: (10748-504)
Supplier: Prosci
Description: TRAF2 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.


Catalog Number: (10680-236)
Supplier: Abnova
Description: Rabbit polyclonal antibody raised against synthetic peptide of TRAF2.


Catalog Number: (103468-024)
Supplier: Affymetrix, Inc.
Description: Suggested positive control: Hela whole cell extract, antigen standard for TRAF2 (transient overexpression lysate). Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF2 is a 502-amino acid protein. Mutagenic studies suggest that the N-terminal RING finger and two adjacent zinc fingers of TRAF2 are required for NF-kB activation, where as interaction with TNFR is mediated through C-terminus domain (5,6). Distinct domains in the N- and -C termini are also required for association with TRAF1 and protein kinase receptor interacting protein (RIP). TRAF2 is involved in cellular resistant to TNF-induced apoptosis. TRAF-2 deficient mice appeared normal at birth, however, they die prematurely, probably due to atrophy of thymus, spleen, muscle mass and lack of TRAF-2's cytoprotective role.

Blocked

Catalog Number: (77526-236)
Supplier: AFG BIOSCIENCE LLC
Description: Human TRAF2 (TNF Receptor-Associated Factor 2) ELISA Kit

New Product


Catalog Number: (10742-654)
Supplier: Abnova
Description: Mouse monoclonal antibody raised against partial recombinant TRAF2.


Catalog Number: (89297-202)
Supplier: Genetex
Description: Goat polyclonal antibody to TRAF2


Catalog Number: (89415-954)
Supplier: Prosci
Description: TRAF2 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.


Catalog Number: (103592-754)
Supplier: Sino Biological
Description: Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human TRAF2, and purified by antigen affinity chromatography.


Catalog Number: (10206-962)
Supplier: Boster Biological Technology
Description: Rabbit IgG polyclonal antibody for TNF receptor-associated factor 2(TRAF2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.


Catalog Number: (10542-126)
Supplier: Abnova
Description: This protein protein interaction Antibody Pair set comes with two antibodies to detect the protein-protein interaction, one against the RALBP1 protein, and the other against the TRAF2 protein for use in Proximity Ligation Assay


Catalog Number: (10742-660)
Supplier: Abnova
Description: Rabbit polyclonal antibody raised against synthetic peptide of TRAF2.


Catalog Number: (89415-956)
Supplier: Prosci
Description: TRAF2 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.


Catalog Number: (10742-658)
Supplier: Abnova
Description: Rabbit polyclonal antibody raised against synthetic peptide of TRAF2.


Catalog Number: (10742-656)
Supplier: Abnova
Description: Goat polyclonal antibody raised against synthetic peptide of TRAF2.


Catalog Number: (10572-846)
Supplier: Abnova
Description: TRAF2 purified MaxPab mouse polyclonal antibody (B01P), Mouse polyclonal antibody raised against a full-length human TRAF2 protein, Size: 50ug


Catalog Number: (10604-552)
Supplier: Abnova
Description: Rabbit polyclonal antibody raised against a full-length human TRAF2 protein.


Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
1 - 16 of 441
no targeter for Bottom