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Catalog Number: (77528-526)
Supplier: AFG BIOSCIENCE LLC
Description: Cattle THP (Tamm–Horsfall Glycoprotein) ELISA Kit

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Catalog Number: (103288-212)
Supplier: Novus Biologicals
Description: The Uromodulin Antibody from Novus Biologicals is a rabbit polyclonal antibody to Uromodulin. This antibody reacts with human. The Uromodulin Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (101076-696)
Supplier: BioVendor
Description: Uromodulin (Tamm-Horsfall protein, UMOD) is approx. 85 kDa glycoprotein that is produced in the thick ascending limb of Henle's loop and early distal convoluted tubules of the nephron.


Catalog Number: (77521-698)
Supplier: AFG BIOSCIENCE LLC
Description: Mouse THP (Tamm–Horsfall Glycoprotein) ELISA Kit

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Catalog Number: (101098-006)
Supplier: Vector Laboratories
Description: Fluorescein labeled Lycopersicon Esculentum (Tomato) Lectin (LEL, TL). Tomato lectin is a very stable single subunit glycoprotein containing about 50 percent arabinose and galactose and may form multimeric aggregates in solution. LEL binds well to glycophorin and Tamm-Horsfall glycoprotein and has been used effectively to label vascular endothelium in rodents.


Catalog Number: (77521-584)
Supplier: AFG BIOSCIENCE LLC
Description: Rat THP (Tamm–Horsfall Glycoprotein) ELISA Kit

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Catalog Number: (77517-024)
Supplier: AFG BIOSCIENCE LLC
Description: Human THP (Tamm–Horsfall Glycoprotein) ELISA Kit

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Catalog Number: (102552-960)
Supplier: BioVendor
Description: Native protein isolated from canine urine, 589 AA, MW: 64,483 kDa (calculated without glycosylation).


Catalog Number: (102552-968)
Supplier: BioVendor
Description: Uromodulin (Tamm-Horsfall protein, UMOD) is approx. 85-kDa glycoprotein that is produced in the thick ascending limb of Henle´s loop and early distal convoluted tubules of the nephron. It is a transmembrane protein, which is secreted into the urine through proteolytic cleavage of the glycosylphosphatidylinositol (GPI) anchor. It belongs to the GPI family. Healthy individuals excrete tens of miligrams of uromodulin per day, making in the most abundant protein in the urine. Uromodulin modulates cell adhesion and signal transduction by interacting with cytokines and it inhibits the aggregation of calcium crystals. By reducing calcium oxalate precipitation, uromodulin plays a protective role with respect to renal stone formation as demonstrated by recent studies on THP- deficient mice prone to nephrolithiasis. THP acts as a host defense factor against urinary tract infections induced by uropathogens such as Esherichia coli, Staphylococcus saphrophyticus, Proteus mirabilis and Klebsiela pneumonie. Uromodulin binds to type 1 fimbriae of Escherichia coli and thereby blocks colonization of urothelial cells. Tamm-Horsfall protein interacts with other molecules and cells including IL-1, IL-2, TNF, IgG, neuthrophils, lymphocytes and monocytes. Binding of uromodulin to neutrophils induces synthesis of IL-8, provokes the respiratory burst and degranulation and stimulates chemotaxis and phagocytosis. Recently, genome-wide association studies identified uromodulin as a risk factor for chronic kidney disease and hypertension. Mutations in the Uromodulin gene are associated with three autosomal dominant tubulo-interstitial nephropathies such as familial juvenile hyperuricemic nephropathy (FJHN), medullary cystic kidney disease (MCKD2) and glomerulocystic kidney disease (GCKD). These disorders are characterized by juvenile onset of hyperuricemia, gout and progressive renal failure.


Catalog Number: (101189-712)
Supplier: BioVendor
Description: Uromodulin (Tamm-Horsfall protein, UMOD) is approx. 85-kDa glycoprotein that is produced in the thick ascending limb of Henle´s loop and early distal convoluted tubules of the nephron. It is a transmembrane protein, which is secreted into the urine through proteolytic cleavage of the glycosylphosphatidylinositol (GPI) anchor. It belongs to the GPI family. Healthy individuals excrete tens of miligrams of uromodulin per day, making in the most abundant protein in the urine. Uromodulin modulates cell adhesion and signal transduction by interacting with cytokines and it inhibits the aggregation of calcium crystals. By reducing calcium oxalate precipitation, uromodulin plays a protective role with respect to renal stone formation as demonstrated by recent studies on THP- deficient mice prone to nephrolithiasis. THP acts as a host defense factor against urinary tract infections induced by uropathogens such as Esherichia coli, Staphylococcus saphrophyticus, Proteus mirabilis and Klebsiela pneumonie. Uromodulin binds to type 1 fimbriae of Escherichia coli and thereby blocks colonization of urothelial cells. Tamm-Horsfall protein interacts with other molecules and cells including IL-1, IL-2, TNF, IgG, neuthrophils, lymphocytes and monocytes. Binding of uromodulin to neutrophils induces synthesis of IL-8, provokes the respiratory burst and degranulation and stimulates chemotaxis and phagocytosis. Recently, genome-wide association studies identified uromodulin as a risk factor for chronic kidney disease and hypertension. Mutations in the Uromodulin gene are associated with three autosomal dominant tubulo-interstitial nephropathies such as familial juvenile hyperuricemic nephropathy (FJHN), medullary cystic kidney disease (MCKD2) and glomerulocystic kidney disease (GCKD). These disorders are characterized by juvenile onset of hyperuricemia, gout and progressive renal failure.


Catalog Number: (103281-826)
Supplier: Novus Biologicals
Description: The Uromodulin Antibody from Novus Biologicals is a rabbit polyclonal antibody to Uromodulin. This antibody reacts with human. The Uromodulin Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (101076-670)
Supplier: BioVendor
Description: Quality control test, Indirect ELISA – to determine titer of the antibody , SDS PAGE – to determine purity of the antibody, and BCA - to determine quantity of the antibody.


Supplier: BioVendor
Description: Native protein isolated from human urine, 590 AA, 64265 kDa (calculated without glycosylation). Protein identity confirmed by LC-MS/MS.

Catalog Number: (76101-720)
Supplier: Bioss
Description: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: Secreted into urine after proteolytical cleavage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.


Catalog Number: (76101-718)
Supplier: Bioss
Description: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: Secreted into urine after proteolytical cleavage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.


Catalog Number: (102684-016)
Supplier: Serotec Inc
Description: TAMM HORSFALL GLYCOPROTE 1ML


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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