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Supplier: Sino Biological
Description: Recombinant human tag-free Tau-441 was co-expressed with PKAc alpha in <i>E. coli</i> cells. The Tau-441 protein was phosphorylated by PKAc alpha <i>in vivo </i>and<i> in vitro</i> prior to the final chromatography purification.

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Catalog Number: (10416-776)
Supplier: Bioss
Description: phosphorylated at the Thr-Pro-Tyr phosphorylation motif instead of the characteristic MAP kinase Thr-Glu-Tyr motif. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53.


Supplier: Adipogen
Description: AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM to 10µM after 24 hour exposure in several rat and human cell models. Likewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation.

Catalog Number: (89361-254)
Supplier: Genetex
Description: Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units. Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000. GS is subject to regulation through both allosteric and covalent modification and occurs in two forms: the phosphorylated inactive form, and the dephosphorylated active form. GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3b that mainly functions to phosphorylate muscle glycogen synthase. This antibody is specific for the phosphorylated form of GS at Ser 640. phosphorylation of GS at S640 has been associated with Antiphospholipid Antibody Syndrome.


Catalog Number: (10358-850)
Supplier: Bioss
Description: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.


Catalog Number: (10541-184)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the CREB1 protein, and the other against the specific S129 Phosphorylated site of CREB1 for use in Proximity Ligation Assay


Catalog Number: (10541-188)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the DNMT1 protein, and the other against the specific Y399 Phosphorylated site of DNMT1 for use in Proximity Ligation Assay


Catalog Number: (10541-216)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the ERBB2 protein, and the other against the specific Y1248 Phosphorylated site of ERBB2 for use in Proximity Ligation Assay


Catalog Number: (10541-536)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the TP53 protein, and the other against the specific S20 Phosphorylated site of TP53 for use in Proximity Ligation Assay


Catalog Number: (10541-472)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the RPS6KA1 protein, and the other against the specific T359 Phosphorylated site of RPS6KA1 for use in Proximity Ligation Assay


Catalog Number: (10541-462)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the RAF1 protein, and the other against the specific S338 Phosphorylated site of RAF1 for use in Proximity Ligation Assay


Catalog Number: (10541-442)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the PRKDC protein, and the other against the specific S2612 Phosphorylated site of PRKDC for use in Proximity Ligation Assay


Catalog Number: (10541-498)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the SLC29A4 protein, and the other against the specific Y198 Phosphorylated site of SLC29A4 for use in Proximity Ligation Assay


Catalog Number: (10541-468)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the RELA protein, and the other against the specific T254 Phosphorylated site of RELA for use in Proximity Ligation Assay


Catalog Number: (10541-138)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the AKT1 protein, and the other against the specific T450 Phosphorylated site of AKT1 for use in Proximity Ligation Assay


Catalog Number: (10541-324)
Supplier: Abnova
Description: This Protein Phosphorylation Antibody Pair set comes with two Antibodies, one against the MAP2K5 protein, and the other against the specific S149 Phosphorylated site of MAP2K5 for use in Proximity Ligation Assay


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