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Catalog Number: (TCV0103-25G)
Supplier: TCI America
Description: CAS Number: 573-20-6
MDL Number: MFCD00021469
Molecular Formula: C15H14O4
Molecular Weight: 258.27
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Color: White
Melting point (°C): 113

Supplier: Ambeed
Description: 2-Methylnaphthalene-1,4-diyl diacetate, Purity: 98%, CAS Number: 573-20-6, Appearance: Form: Crystal - Powder/Colour: White - Very pale yellow, Storage: Sealed in dry, Room Temperature, Size: 250mg

Catalog Number: (RL600-401-J98)
Supplier: Rockland Immunochemical
Description: Anti-Histone H3 K4-Me3/K9-Ac antibody is useful for dot blot and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~15.4kDa corresponding to the appropriate cell lysate or extract.


Catalog Number: (76752-534)
Supplier: Prosci
Description: Anti-H3K4ac (acetylated) Rabbit Polyclonal Antibody


Catalog Number: (10432-536)
Supplier: Bioss
Description: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.


Catalog Number: (77687-781)
Supplier: AFG BIOSCIENCE LLC
Description: Recommended dilution: ICC:1:1-1:10, IF:1:1-1:10

New Product


Catalog Number: (10432-538)
Supplier: Bioss
Description: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.


Catalog Number: (77698-022)
Supplier: AFG BIOSCIENCE LLC
Description: Recommended dilution: WB:1:500-1:5000

New Product


Catalog Number: (77687-780)
Supplier: AFG BIOSCIENCE LLC
Description: Recommended dilution: WB:1:200-1:2000, ICC:1:10-1:100, IF:1:10-1:100, IP:1:200-1:2000

New Product


Catalog Number: (10432-540)
Supplier: Bioss
Description: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.


Catalog Number: (75929-760)
Supplier: Rockland Immunochemical
Description: Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing corepressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.


Catalog Number: (103007-758)
Supplier: Anaspec Inc
Description: This is a FAM (Abs/Em = 492/518 nm) labeled histone 3 (H3) amino acid residues 1 to 21 with lysine 4 methylated.
Sequence:ART-K(Me1)-QTARKSTGGKAPRKQLA-GGK(FAM)-NH2
MW:2868.2 Da
% peak area by HPLC:95
Storage condition:-20° C


Catalog Number: (77691-279)
Supplier: AFG BIOSCIENCE LLC
Description: Recommended dilution: WB:1:500-1:2000, ICC:1:50-1:500, IF:1:30-1:200

New Product


Catalog Number: (77687-915)
Supplier: AFG BIOSCIENCE LLC
Description: Recommended dilution: WB:1:100-1:1000, ICC:1:20-1:200, IF:1:10-1:100

New Product


Catalog Number: (10427-666)
Supplier: Bioss
Description: SMYD3 is a gene that is over-expressed in the majority of colorectal carcinomas and hepatocellular carcinomas. SMYD3 forms a complex with RNA polymerase II through an interaction with the RNA helicase HELZ and transactivates a set of genes that included oncogenes, homeobox genes and genes associated with cell-cycle regulation. SMYD3 binds to a motif, 5'-CCCTCC-3', present in the promoter region of downstream genes such as Nkx2.8. The SET domain of SMYD3 shows histone H3-lysine 4 (H3-K4)-specific methyltransferase activity, which is enhanced in the presence of the heat-shock protein HSP90A.


Catalog Number: (10427-660)
Supplier: Bioss
Description: SMYD3 is a gene that is over-expressed in the majority of colorectal carcinomas and hepatocellular carcinomas. SMYD3 forms a complex with RNA polymerase II through an interaction with the RNA helicase HELZ and transactivates a set of genes that included oncogenes, homeobox genes and genes associated with cell-cycle regulation. SMYD3 binds to a motif, 5'-CCCTCC-3', present in the promoter region of downstream genes such as Nkx2.8. The SET domain of SMYD3 shows histone H3-lysine 4 (H3-K4)-specific methyltransferase activity, which is enhanced in the presence of the heat-shock protein HSP90A.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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