You Searched For: Uracil,+[5,6-3H]


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Catalog Number: (10348-944)
Supplier: Bioss
Description: Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.


Catalog Number: (10450-102)
Supplier: Bioss
Description: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


Catalog Number: (MSPP-PAG917HU1)
Supplier: CLOUD-CLONE CORP MS
Description: Polyclonal antibody to Uracil DNA Glycosylase (UNG), derived from recombinant UNG(Met1~Leu313), is reactive with Human/Mouse/Rat/Pig.

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Catalog Number: (76108-482)
Supplier: Bioss
Description: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.


Catalog Number: (102834-720)
Supplier: Matrix Scientific
Description: 5,6-Diaminopyrimidine-2,4-dithiol ≥97%


Catalog Number: (10166-608)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to UNG (uracil-DNA glycosylase)


Catalog Number: (101640-950)
Supplier: New England Biolabs (NEB)
Description: Human single-strand-selective monofunctional uracil-DNA Glycosylase (hSMUG1) excises deoxyuracil and deoxyuracil-derivatives bearing an oxidized group at C5, such as 5-hydroxyuracil, 5-hydroxymethyluracil and 5-formyluracil in ssDNA and dsDNA.

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Catalog Number: (10326-454)
Supplier: Bioss
Description: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


Catalog Number: (10450-368)
Supplier: Bioss
Description: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


Catalog Number: (10348-924)
Supplier: Bioss
Description: Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.


Catalog Number: (10108-964)
Supplier: Prosci
Description: UPB1 is a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activityThis gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.


Catalog Number: (10099-812)
Supplier: Prosci
Description: SLC23A3 is a multi-pass membrane protein. It belongs to the xanthine/uracil permease family, SLC23A subfamily. The exact function of SLC23A3 remains unknown.


Catalog Number: (89416-074)
Supplier: Prosci
Description: UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.


Catalog Number: (10299-992)
Supplier: Bioss
Description: G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.


Catalog Number: (10326-846)
Supplier: Bioss
Description: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


Supplier: Ambeed
Description: Carmofur 98%

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