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Tricyclic amide linker resin (DL-form) 200-400 mesh

Supplier: Bachem Americas
Description: Ramage resin is highly suitable for the preparation of peptide amides by the Fmoc-strategy and is recommended for C-terminal Phe, Tyr and Ile. Cleavage has been performed with 50 % TFA in CH₂Cl₂ or 95% aqueous TFA. Scavengers may be required. Tricyclic amide linker resin has been used for the synthesis of fluorogenic substrates for continuous assay of aminopeptidase P. Bachem additionally offers the Ramage amide linker (Q-2745) to be coupled to other types of carrier resin.

Image Unavailable-D-2040.0005BA

Xanthenyl linker resin 200-400 mesh

Supplier: Bachem Americas
Description: Sieber amide resin has been developed for the Fmoc-SPPS of fully t-butyl protected peptide amides. Cleavage can be achieved with 1% TFA in methylene chloride. Scavengers may be required. As N-methylation increases the acid-lability of the peptide bond, Malakoutikhah et al. employed Sieber resin for obtaining short peptide amides containing multiple MePhe residues.

Image Unavailable-D-1675.0005BA

Rink amide AM resin 200-400 mesh

Supplier: Bachem Americas
Description: Fmoc-Rink amide-AM resin, a standard resin for the Fmoc-SPPS of peptide amides. Cleavage was performed with 50 % TFA in CH₂Cl₂ or 95% aqueous TFA. Scavengers may be required. Bachem additionally offers the Rink amide (RAM) linker (Q-1660).

Image Unavailable-D-2125.0001BA

PAL resin 200-400 mesh

Catalog Number: (D-2125.0001BA)
Supplier: Bachem Americas
Description: Useful for the synthesis of peptide amides using Fmoc strategy. Cleavage has been performed with 50 % TFA in CH₂Cl₂ or 95% aqueous TFA. Scavengers may be required.
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EDC-HCl (N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride) crosslinker

Supplier: G-Biosciences
Description: EDC is a heterobifunctional, water-soluble, zero-length carbodiimide crosslinker that is used to couple carboxyl groups to primary amines. EDC activates carboxyl groups first and forms amine reactive O-acylisourea imtermediate that spontaneously reacts with primary amines to form an amide bond and isourea by-product.

Image Unavailable-103871-810

Sulfo-NHS-LC-Biotin, EZ-Link™ No-Weigh™ Format, Pierce™

Catalog Number: (103871-810)
Supplier: Invitrogen
Description: Thermo Scientific EZ-Link Sulfo-NHS-LC-Biotin is an intermediate-length, water-soluble biotinylation reagent for labeling antibodies, proteins and other molecules that have primary amines.

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Image Unavailable-103009-508

[Cit 2/8/17]-Histone H3 (1-21)-GGK,Biotin

Catalog Number: (103009-508)
Supplier: Anaspec Inc
Description: This is histone H3 (1-21) with deimination of Arg2, Arg8, and Arg17 to Citrulline (Cit). Its C-terminal is biotinylated through a GGK linker and blocked by an amide group. Deimination by peptidyl arginine deiminase 4 (PADI4) prevents methylation at these sites and blocks transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:A-Cit-TKQTA-Cit-KSTGGKAP-Cit-KQLA-GGK(Biotin)-NH2
MW:2725.2 Da
% peak area by HPLC:95
Storage condition:-20° C
Product Image-76481-696

3-Maleimidopropionic acid N-hydroxysuccinimide ester

Catalog Number: (76481-696)
Supplier: AAT BIOQUEST INC
Description: 3-Maleimidopropionic acid N-hydroxysuccinimide ester is a non-cleavable and membrane permeable crosslinker.

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DSG (Disuccinimidyl glutarate), Pierce™

Supplier: Invitrogen
Description: Thermo Scientific Pierce DSG is a water-insoluble, homo-bifunctional N-hydroxysuccinimide ester (NHS-ester) crosslinker often used for conjugating radiolabeled ligands to cell-surface receptors. The NHS ester is the simplest and most commonly used reactive group for crosslinking and labeling proteins and peptides. NHS esters react with primary amines on the N-termini of peptides and the  amine of lysine residues, forming a stable, covalent amide bond and releasing the NHS group.

Certificates

Product Image-76481-686

SMCC (N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate) ≥85%

Supplier: AAT BIOQUEST INC
Description: SMCC is a non-cleavable and membrane permeable crosslinker with a spacer arm of 8.3 Å. It contains an amine-reactive succinimidyl ester (SE) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7 to 9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5 to 7.5 to form stable thioether bonds. The SE group of SMCC is reacted with lysine residues on the carrier protein, converting them to reactive maleimides. SMCC is a reagent that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls. Alternatively these relatively stable maleimide-activated intermediates may be lyophilized and stored for later conjugation to a hapten.

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Product Image-PI22981

EDC-HCl (N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride), Pierce™

Supplier: Invitrogen
Description: Thermo Scientific Pierce EDC is a carboxyl- and amine-reactive zero-length crosslinker. EDC reacts with a carboxyl group first and forms an amine-reactive O-acylisourea intermediate that quickly reacts with an amino group to form an amide bond with release of an isourea by-product. The intermediate is unstable in aqueous solutions and so two-step conjugation procedures rely on N-hydroxysuccinimide (NHS) for stabilization. Failure to react with an amine will result in hydrolysis of the intermediate, regeneration of the carboxyl, and release of an N-substituted urea. A side reaction is the formation of an N-acylurea, which is usually restricted to carboxyls located in hydrophobic regions of proteins.

SDS Certificates

Image Unavailable-103523-926

SMCC (N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate), No-Weigh™ Format, Pierce™

Catalog Number: (103523-926)
Supplier: Invitrogen
Description: Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

Certificates


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PMPI (4-Maleimidophenyl isocyanate) ≥97.0%, purum, Sigma-Aldrich®

Supplier: Sigma Aldrich
Description: SPB is an amine-reactive and photoreactive heterobifunctional crosslinking reagent. The photoreactive psoralen group provides much greater covalent insertion yields than phenyl azide-containing compounds, which makes this reagent a superior alternative to typical photoreactive NHS-ester crosslinkers. The psoralen tricyclic planar ring system intercalates into double-stranded, and to a lesser extent, single-stranded, DNA, RNA, PCR products, cDNA or oligonucleotides. It also can be used with agarose gel-purified oligonucleotides because the presence of agarose does not interfere with the coupling reaction. The nucleic acid labeling site of the psoralen group (the 5,6 double bond in thymine residues) does not interfere with subsequent hybridization reactions, creating a highly-sensitive direct labeling alternative to radioactive probes.

Image Unavailable-103008-716

Histone H4 (1-23)-GGK, Biotin

Catalog Number: (103008-716)
Supplier: Anaspec Inc
Description: This peptide is of Histone H4 (1-23) biotinylated through a GGK linker on the C-terminus. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:SGRGKGGKGLGKGGAKRHRKVLR-GGK(Biotin)-NH2
MW:2828.4 Da
% peak area by HPLC:95
Storage condition:-20° C
Product Image-103523-934

Sulpho-NHS-LC-LC-Biotin, EZ-Link™, Pierce™

Supplier: Invitrogen
Description: Thermo Scientific EZ-Link Sulfo-NHS-LC-LC-Biotin enables simple and efficient biotin labeling of antibodies, proteins, and any other primary amine–containing macromolecules. Specific labeling of cell surface proteins is another common application for these uniquely water-soluble and membrane impermeable reagents.

SDS Certificates

Product Image-PI22360

SMCC (N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate), Pierce™

Catalog Number: (PI22360)
Supplier: Invitrogen
Description: Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

SDS Certificates


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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