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VWR® Digital Outlet Controller

Catalog Number: (61161-343)

Supplier: VWR International

Description: Versatile and economical controller programs equipment on and off at any minute of any day.

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VWR® Four-Channel Electronic Timer and Clock with Certificate of Calibration

Catalog Number: (89203-042)

Supplier: VWR International

Description: This 4-channel timer has a capacity of 99 hours, 59 minutes and 59 seconds or can be switched to a 12- or 24-hour clock.

Certificates

Professional Time Switches, Capewell Aerial Systems LLC

Supplier: M H Rhodes

Description: Time switch has built-in three-wire, grounded plug and receptacle.

Accupulser™ A310 Signal Generator

Catalog Number: (77665-170)

Supplier: WORLD PRECISION INSTRUMENTS LLC

Description: The A310 pulse generator/stimulator combines the reproducibility and accuracy of digital electronics with the fine resolution and continuous adjustment possible with analog circuitry. All timing parameters are entered with high resolution, ten-turn potentiometers and six-position range switches. Timing is accurate to within 1% of the set value.

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UVP Portable/Rechargeable UV Lamps, Analytik Jena

Supplier: Analytik Jena US

Description: Rechargeable -26P Series UV Lamps offer versatility and variety in a powerful 6/12 watt rechargeable design. UVS-26P has two shortwave tubes. This model allows you to use two tubes at a time, or just one. UVL-26P has two longwave ultraviolet tubes. This model allows use of one or two tubes at a time. UVSL-26P has one shortwave and one longwave UV tube. This model allows use of one tube at a time. The toggle switch allows users to easily select longwave or shortwave UV.

CryoPlus™ Vapor Phase Starter Kits, Thermo Scientific

Supplier: Thermo Fisher Scientific

Description: The top-mounted control panel allow easy access to the microprocessor controller for programming. Security features like rear-mounted recessed power switch to prevent accidental power shut-off. Counterbalanced lid with 100% clearance allows each entry into the storage area for retrieval of samples while minimizing exposure time. Temperature sleeve incorporated, providing colder temperatures at the top and a more efficient vapor phase operation.

Chromaster HPLC System, Hitachi

Supplier: HITACHI HIGH-TECH AMERICA, INC.

Description: The Chromaster HPLC system has established new limits in performance, ease of use, and robustness. Its design incorporates an extremely low dwell volume and a very low carry-over. In combination with very sensitive detector technology, especially the fluorescence detector, the Chromaster HPLC system is one of the strongest LC systems on the market. A huge amount of accessories and a modular set-up, enable an easy adaption to all customer needs, whether if it is used for an aggressive industrial or a high sensitive pharma application. VWR's relationship with Hitachi started over 30 years ago as a Merck Hitachi cooperation. During this time, the robustness and reliability of the Hitachi HPLC instruments has helped to build and develop a strong partnership.

Anti-BRG-1/SMARCA4/SNF2 beta Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))

Catalog Number: (10306-792)

Supplier: Bioss

Description: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

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Anti-SMARCA4 Rabbit Polyclonal Antibody

Catalog Number: (10070-418)

Supplier: Prosci

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Orbital Platform Shaker, PSU-10i, Grant Instruments

Catalog Number: (89194-490)

Supplier: GRANT USA INC.

Description: Microprocessor controlled shaking platform providing smooth and quiet horizontal orbital motion for mixing in bottles, flasks and beakers

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Battery Backpack Vac, Atrix

Catalog Number: (100720-986)

Supplier: Atrix International

Description: The Atrix Battery Backpack is perfect for cleaning confined areas and where corded electric vacuums are not a viable option

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Anti-ARRB1/Beta-arrestin 1 Rabbit Polyclonal Antibody

Catalog Number: (77438-962)

Supplier: Bioss

Description: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6). Involved in IL8-mediated granule release in neutrophils.