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Supplier: Simport Scientific
Description: Molded from acetal, these patented cassettes keep specimens safely submerged in liquid and are resistant to most histological solvents. The anterior writing area is at a 45° angle to make the cassette more suitable to be used with most types of cassette labeling instruments.

Catalog Number: (103409-678)
Supplier: Novus Biologicals
Description: The ABCG5 Antibody (1B5E10) from Novus Biologicals is a mouse monoclonal antibody to ABCG5. This antibody reacts with human. The ABCG5 Antibody (1B5E10) has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, ICC / IF (Negative).


Catalog Number: (103406-486)
Supplier: Novus Biologicals
Description: The ABCG2 / CD338 Antibody (3G8) from Novus Biologicals is a mouse monoclonal antibody to ABCG2 / CD338. This antibody reacts with human, mouse, primate. The ABCG2 / CD338 Antibody (3G8) has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.


Catalog Number: (103409-680)
Supplier: Novus Biologicals
Description: The ABCG5 Antibody (1B5E10) from Novus Biologicals is a mouse monoclonal antibody to ABCG5. This antibody reacts with human. The ABCG5 Antibody (1B5E10) has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, ICC / IF (Negative).


Catalog Number: (103406-500)
Supplier: Novus Biologicals
Description: The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 680] from Novus Biologicals is a mouse monoclonal antibody to ABCG2 / CD338. This antibody reacts with human. The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 680] has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (103406-492)
Supplier: Novus Biologicals
Description: The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 350] from Novus Biologicals is a mouse monoclonal antibody to ABCG2 / CD338. This antibody reacts with human. The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 350] has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (103406-494)
Supplier: Novus Biologicals
Description: The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 405] from Novus Biologicals is a mouse monoclonal antibody to ABCG2 / CD338. This antibody reacts with human. The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 405] has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (103406-498)
Supplier: Novus Biologicals
Description: The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 488] from Novus Biologicals is a mouse monoclonal antibody to ABCG2 / CD338. This antibody reacts with human. The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 488] has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (103406-490)
Supplier: Novus Biologicals
Description: The ABCG2 / CD338 Antibody (MM0047-2J39) [Allophycocyanin] from Novus Biologicals is a mouse monoclonal antibody to ABCG2 / CD338. This antibody reacts with human. The ABCG2 / CD338 Antibody (MM0047-2J39) [Allophycocyanin] has been validated for the following applications: Flow Cytometry.


Catalog Number: (103406-488)
Supplier: Novus Biologicals
Description: The ABCG2 / CD338 Antibody (3G8) from Novus Biologicals is a mouse monoclonal antibody to ABCG2 / CD338. This antibody reacts with human, mouse, primate. The ABCG2 / CD338 Antibody (3G8) has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.


Catalog Number: (103406-502)
Supplier: Novus Biologicals
Description: The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 755] from Novus Biologicals is a mouse monoclonal antibody to ABCG2 / CD338. This antibody reacts with human. The ABCG2 / CD338 Antibody (MM0047-2J39) [DyLight 755] has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.


Catalog Number: (89153-246)
Supplier: Enzo Life Sciences
Description: Bile Salts
Bile salts are important physiological agents that serve a number of functions, including absorption, solubilization, transport and secretion of lipids. In the liver, they participate in the generation of bile flow and the secretion of cholesterol and phospholipids, such as phosphatidylcholine. When released into the intestine, they facilitate the uptake of cholesterol, fat-soluble vitamins and other lipids. Moreover, the biosynthesis of bile acids from cholesterol is the most significant pathway for the elimination of cholesterol from the body. However, because of their detergent properties, bile acids are inherently cytotoxic and disruptions in their normal transport or secretion can result in a variety of pathophysiological conditions.

BSEP
Bile formation is an important function of the liver. It is mediated by hepatocytes which generate bile flow within the bile canaliculi by continuous vectorial secretion of bile salts and other solutes across their canalicular (apical) membrane. Bile secretion is mediated by several ATP-binding cassette (ABC) transporters located in the canalicular membrane of hepatocytes. Among these ABC transporters, the bile salt export pump (BSEP or ABCB11) represents the primary, if not sole transport system for the canalicular excretion of bile salts. Bile secretory failure results in cholestasis and progressive familial intrahepatic cholestasis (PFIC) in infancy represents a group of inherited cholestatic diseases that are classified into three subtypes. One of these subtypes, PFIC II, is associated with mutations in the BSEP gene. PFIC patients with mutations in the BSEP gene have normal γ-glutamyltransferase activity, low concentrations of bile salts in bile, and an absence of bile duct proliferation. Additionally, human obesity is associated with altered cholesterol homeostasis including increased production and turnover, as well as secretion of excess cholesterol from the liver into bile.

BSEP is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-ancoring domain and an ATP-binding cassette (ABC) domain. The membrane-anchoring domain is composed of six helixes buried in the lipid bilayer of the plasma membrane and the ATP binding ABCs are exposed to the cytosol. The membrane-anchoring domain helixes are thought to form channels spanning the plasma membrane.


Supplier: Sklar
Description: DeBakey Atraumatic Tangential Occlusion Clamp is a ratcheted, finger ring clamp used in cardiovascular procedures to provide partial clamping of vessels.

Supplier: Ace Glass
Description: The rugged cylindrical reaction flask with Duran style flat o-ring groove flange, is for use with quick release clamp

Small Business Enterprise Product available on GSA Advantage®

Catalog Number: (10251-132)
Supplier: Bioss
Description: Dbx1 homeodomain transcription factor is expressed in progenitors at the boundary between the dorsal and ventral plates of the caudal neural tube, from which postmitotic cells migrate tangentially to their final destination. Dbx1 is implicated in patterning the central nervous system during embryogenesis. Cell fate allocation and cell diversity are determined at very early stages in progenitor cells at precise coordinates along the dorsoventral and anteroposterior axis. In the spinal cord, the spatially restricted expression of Dbx1 in progenitors is critical in establishing interneuron cell fates and helps coordinate diverse phenotypic features. In the telencephalon, Dbx1 is expressed in restricted progenitor domains at the borders of the developing pallium.


Supplier: Electron Microscopy Sciences
Description: Puchtler-Sweat Method for Basement Membranes, Puchtler and Sweat (1964), Stain results - Basement Membranes: Black in cross section/Gray in tangential sections, Nuclei: Pink to Red

Minority or Woman-Owned Business Enterprise

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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