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Product Image-97062-922

Ribonuclease Inhibitor (RNase Inhibitor)

Description: RNase Inhibitor is used to inhibit the activity of RNases in reaction mixtures for cDNA synthesis and in vitro transcription, as well as for long term storage of valuable RNA samples
Catalog Number: 97062-922
Supplier: VWR

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Product Image-77750-790

Human Recombinant HB-EGF (from E. coli)

Description: Heparin-binding EGF-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family and is expressed by monocytes and macrophages. HB-EGF is the predominant growth factor involved in epithelialization during wound healing. HB-EGF signals through the receptor tyrosine kinase ErbB2 to maintain adult heart homeostasis, and promotes cardiac valve development through binding in high affinity to the epidermal growth factor receptor (EGFR). HB-EGF binds the the ErbB4 receptor tyrosine kinase to mediate implantation of the human blastocyst. HB-EGF also functions as a potent mitogen for fibroblasts and smooth muscle cells.
Catalog Number: 77750-790
Supplier: VWR International

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Product Image-77751-810

Human Recombinant IL-15 (from E. coli)

Description: <p>Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Therefore, IL-15 may serve as an effective therapeutic target, due to the beneficial outcomes of IL-15 neutralization in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells.</p>
Catalog Number: 77751-810
Supplier: VWR International

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Product Image-77750-972

Human Recombinant PLGF-3 (from E. coli)

Description: Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and promotes endothelial cell growth and angiogenesis. PlGF is secreted as a homodimer and may also form a heterodimer with VEGF. PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues. Circulating PlGF levels are correlated with colorectal and renal cancers, as well as atherosclerosis and ischemic heart disease. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 lacks a heparin-binding domain and signals through the VEGFR-1 receptor.
Catalog Number: 77750-972
Supplier: VWR International

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Product Image-JT0440-4

J.T.Baker®, Chicken Native Albumin (from Egg)

Description: Albumin, Egg, Powder, Purified
Catalog Number: JT0440-4
Supplier: AVANTOR PERFORMANCE MATERIALS US

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Product Image-JTA464-2

VWR® Bovine Serum Albumin (BSA), Fraction V

Description: Fraction V.
Catalog Number: JTA464-2
Supplier: AVANTOR PERFORMANCE MATERIALS US

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Product Image-77750-876

Human Recombinant PDGF-BB (from E. coli)

Description: Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β, and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β.
Catalog Number: 77750-876
Supplier: VWR International

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Product Image-77752-724

Mouse Recombinant IL-10 (from E. coli)

Description: Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.  IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ƴ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells.  IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells. Mouse IL-10 is not active on human cells.
Catalog Number: 77752-724
Supplier: VWR International

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Product Image-97062-506

Bovine Serum Albumin (BSA)

Description: Crystalline. Prepared by a cold alcohol isolation procedure. This salt-free preparation is the purest material ideal for sensitive biochemical and diagnostic assays. DNase- and RNase-free, virtually free of globulins and other interfering contaminants.
Catalog Number: 97062-506
Supplier: VWR

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Product Image-77753-360

Human Recombinant IL-3 (from E. coli)

Description: IL-3 is a species-specific cytokine and pleiotropic growth factor that promotes the survival, differentiation, and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil, and mast cell lineages. Produced by T cells, mast cells, and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Catalog Number: 77753-360
Supplier: VWR International

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Product Image-97061-068

VWR® Glycylglycine (Gly-Gly)

Description: Biological buffers are useful for cell culture <i>in vitro</i>, enzyme assays and some electrophoretic applications at physiological pH.
Catalog Number: 97061-068
Supplier: VWR

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Product Image-77751-802

Human Recombinant IL-15 (from E. coli)

Description: <p>Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Therefore, IL-15 may serve as an effective therapeutic target, due to the beneficial outcomes of IL-15 neutralization in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells.</p>
Catalog Number: 77751-802
Supplier: VWR International

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Product Image-77753-362

Human Recombinant RH IL-4 (from E. coli)

Description: IL-4 is an immunomodulatory cytokine that stimulates B cell proliferation and activates eosinophils, basophils, and mast cells. Induces vascular cell adhesion molecule (VCAM)-1 expression on endothelial cells and involved in collagen production by fibroblasts. Plays a key role in promotion of Th2 differentiation from naïve helper T cells. Defines the Th2 phenotype of lymphocytes. Regulates cell proliferation, apoptosis, and expression of numerous genes in various cell types. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Catalog Number: 77753-362
Supplier: VWR International

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Product Image-77750-806

Human Recombinant HB-EGF (from E. coli)

Description: Heparin-binding EGF-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family and is expressed by monocytes and macrophages. HB-EGF is the predominant growth factor involved in epithelialization during wound healing. HB-EGF signals through the receptor tyrosine kinase ErbB2 to maintain adult heart homeostasis, and promotes cardiac valve development through binding in high affinity to the epidermal growth factor receptor (EGFR). HB-EGF binds the the ErbB4 receptor tyrosine kinase to mediate implantation of the human blastocyst. HB-EGF also functions as a potent mitogen for fibroblasts and smooth muscle cells.
Catalog Number: 77750-806
Supplier: VWR International

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Product Image-77751-068

Human Recombinant AMPHIREGULIN (from E. coli)

Description: Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family. AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR). AR promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium. Up-regulated at puberty, AR promotes ductal outgrowth and mammary branching. In the liver, AR functions as a mitogen and prevents hepatocyte apoptosis. In a cancer context, AR protects against human adenocarcinoma apoptosis, promotes tumor cell growth, and functions as an oncogenic factor in the Hippo pathway. AR levels are increased in the brain following stress events, such as inflammation, ischemia, and hypoxia.
Catalog Number: 77751-068
Supplier: VWR International

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Image Unavailable-10791-790

VWR® Bovine Serum Albumin (BSA)

Description: Concentrated 30% BSA solution (Albumin, Bovine, Fraction V – Cold Alcohol Isolation) in 0.85% sodium chloride and contains 0.1% sodium azide (as a preservative for stability).
Catalog Number: 10791-790
Supplier: VWR

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273 - 288 of 6,559