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Product Image-10752-174

Anti-CFTR Rabbit Polyclonal Antibody

Catalog Number: (10752-174)
Supplier: Prosci
Description: The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily, and a member of the MRP subfamily that is involved in multi-drug resistance. CFTR functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorder cystic fibrosis, the most common, fatal, inherited disease of caucasian populations.
Product Image-10029-336

Split Specimen Collection Kits, Therapak®

Supplier: Therapak, LLC
Description: For drugs of abuse testing applications requiring two samples to be collected from a single donor, the split specimen collection and transport kits are available in either a split bag kit or the same kit within a transport box.

Product Image-10109-760

Anti-UGT1A4 Rabbit Polyclonal Antibody

Catalog Number: (10109-760)
Supplier: Prosci
Description: UGT1A4 is an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
Product Image-89013-346

Hemoccult® ICT Immunochemical Fecal Occult Blood Test, Beckman Coulter®

Supplier: Hemocue
Description: This immunochemical fecal occult blood test features high specificity and sensitivity, and is clinically proven to detect bleeding associated with more cancers and polyps than traditional guaiac-based tests.

Product Image-76299-868

Leak Resistant Urine Collection Containers with Patient I.D. Label, Globe Scientific

Supplier: Globe Scientific
Description: These containers are the ultimate in leak-tight storage and transport of liquids.

Product Image-10146-678

Micro-Touch® Affinity® 3770 Polychloroprene Examination Gloves, Ansell

Supplier: Ansell Healthcare
Description: Micro-Touch Affinity examination gloves provide the fit, comfort, tactile sensitivity and stretchability of natural rubber latex without the risks associated with NRL or glove powder complications.

Product Image-10797-470

Mouse IgG1 Isotype Control

Catalog Number: (10797-470)
Supplier: Prosci
Description: Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Image Unavailable-89366-680

Anti-Influenza A Mouse Monoclonal Antibody

Catalog Number: (89366-680)
Supplier: Genetex
Description: Infectious diseases are the leading cause of death worldwide. AIDS, tuberculosis (TB), malaria, diarrhoeal and respiratory infections account for 78% of deaths caused by infectious disease. As many infectious diseases are controlled, new diseases emerge and old diseases become resistant to current drugs. Many infectious diseases have been associated with an increase risk of carcinoma. Influenza continues to attract researchers as new strains appear by the ability of the influenza gene to mix with different forms of the virus. Recently, research on SARS and West Nile virus has risen due to the increased number of infections. These antibodies assist in research by detecting the infectious disease agent.
Product Image-10075-368

Anti-TH Rabbit Polyclonal Antibody

Catalog Number: (10075-368)
Supplier: Prosci
Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004).
Image Unavailable-75854-232

Force EXP Guard Column Cartridges, Restek

Supplier: Restek
Description: Free-Turn architecture lets you change cartridges by hand without breaking inlet/outlet fluid connections, with no tools needed.

Product Image-32916-676

Supreno® EC Powder-Free Nitrile Gloves, Microflex®, Ansell

Supplier: Ansell Healthcare
Description: Soft, durable nitrile formulation delivers improved comfort, strength and durability for maximum protection against rips, snags or tears

Product Image-10751-118

Anti-MFSD2A Rabbit Polyclonal Antibody

Catalog Number: (10751-118)
Supplier: Prosci
Description: MFSD2A Antibody: Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.
Product Image-10751-120

Anti-MFSD2B Rabbit Polyclonal Antibody

Catalog Number: (10751-120)
Supplier: Prosci
Description: MFSD2B Antibody: Multidrug transporters, such as MFSD2B, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2B is closely related to MFSD2A, which is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting, playing a major role in the induction of MFSD2A expression during adaptive thermogenesis. Unlike MFSD2A, MFSD2B is expressed in few tissues and at relatively low levels, and is not induced during fasting, suggesting that MFSD2B may play other roles.
Product Image-89047-952

Rxi®-1ms Capillary Columns, Restek

Supplier: Restek
Description: Inert, low-bleed columns for reliable column-to-column results from low-level GC/MS analyses provide reproducible retention and selectivity.

Image Unavailable-89352-442

Anti-FK506 Mouse Monoclonal Antibody

Catalog Number: (89352-442)
Supplier: Genetex
Description: FK 506 antigen is a novel macrolide with similar but more potent immunosuppressant activity than cyclosporine. FK 506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant FK506 side effects are nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension. Most of these side effects are more closely related to FK 506 blood levels than dosage; therefore therapeutic drug monitoring (TDM) of FK506 levels is a prerequisite for therapy. Whole blood is the matrix of choice for FK 506 TDM. The whole blood target level range aimed for in clinical practice is between 3.0 and 20.0 ng/ml and depends on the patient's liver function, the type of organ transplanted and the time after transplantation.
Product Image-10751-824

Anti-CHCHD6 Rabbit Polyclonal Antibody

Catalog Number: (10751-824)
Supplier: Prosci
Description: CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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