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Image Unavailable-76109-476

Anti-GIPC-2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76109-476)
Supplier: Bioss
Description: GIPC2 is a 315 amino acid protein that localizes to the cytoplasm and contains one PDZ domain. Expressed at high levels in kidney and colon and at lower levels in adult liver, GIPC2 interacts with SEMA5A and is thought to function as a scaffold protein, possibly modulating cell adhesion and growth factor signaling and playing a role in tumorigenesis. The gene encoding GIPC2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Image Unavailable-10399-466

Anti-ANXA7 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10399-466)
Supplier: Bioss
Description: The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A7 is a member of the annexin family of calcium dependent phospholipid binding proteins. The Annexin A7 gene contains 14 exons and spans approximately 34 kb of DNA. Structural analysis of the protein suggests that Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion.
Image Unavailable-75794-110

Mouse Recombinant Profilin Toxoplasma gondii (from E. coli)

Catalog Number: (75794-110)
Supplier: Prosci
Description: TLR11, an innate sensor for profilin (Toxoplasma gondii), is an intracellular receptor that resides in the endoplasmic reticulum. The 12 membrane-spanning endoplasmic reticulum-resident protein UNC93B1 interacts directly with TLR11 and regulates the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12, a previously uncharacterized TLR, also recognizes profilin from Toxoplasma gondii. TLR12 is sufficient for recognition of profilin by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.
Product Image-10071-000

Anti-THOC1 Rabbit Polyclonal Antibody

Catalog Number: (10071-000)
Supplier: Prosci
Description: Prostein is a novel prostate-specific protein expressed in normal and malignant prostate tissues. This protein appears tobe a type IIIa plasma membrane protein with a cleavable signal peptide and 11 transmembrane-spanning regions. Prostein expression is androgen responsive since treatment of LNCaP cells with androgen up-regulates prostein message and protein expression levels. Thus, prostein is a prostate-specific marker whose detection and quantitationmay be useful in diagnosing and monitoring prostate cancer.
Product Image-10108-088

Anti-NCL Rabbit Polyclonal Antibody

Catalog Number: (10108-088)
Supplier: Prosci
Description: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus.Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
Image Unavailable-89367-848

Anti-CD20 Mouse Monoclonal Antibody [clone: 2H7]

Catalog Number: (89367-848)
Supplier: Genetex
Description: Mouse monoclonal [2H7] to human CD20;Azide Free
Product Image-76011-556

Anti-ZMYND10 Rabbit Polyclonal Antibody

Catalog Number: (76011-556)
Supplier: Prosci
Description: BLU is a candidate tumor suppressor gene, that spans 4.5 kb on 3p21.3. It encodes a 50 kd protein, which is commonly found in transcription repressors. It is suspected that BLU has a function in cell cycle progression. BLU is a stress-responsive gene regulated by E2F.12 It is commonly found to be downregulated in non-small cell lung cancer, esophagus squamous cell carcinoma and nasopharyngeal carcinoma (NPC).
Image Unavailable-102980-208

Toxoplasma gondii Recombinant Profilin (from Escherichia coli)

Supplier: Adipogen
Description: TLR11, an innate sensor for profilin (Toxoplasma gondii), is an intracellular receptor that resides in the endoplasmic reticulum. The 12 membrane-spanning endoplasmic reticulum-resident protein UNC93B1 interacts directly with TLR11 and regulates the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12, a previously uncharacterized TLR, also recognizes profilin from Toxoplasma gondii. TLR12 is sufficient for recognition of profilin by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.

Image Unavailable-76117-730

Anti-RNF139 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76117-730)
Supplier: Bioss
Description: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
Product Image-10748-666

Anti-ORAI2 Rabbit Polyclonal Antibody

Catalog Number: (10748-666)
Supplier: Prosci
Description: ORAI2 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1.
Image Unavailable-75921-030

Anti-MYC Mouse Monoclonal Antibody [clone: 9E10.]

Catalog Number: (75921-030)
Supplier: Biotium
Description: This antibody recognizes a transcription factor of 64-67 kDa, identified as c-myc. Its epitope spans aa 410-419 (EQKLISEEDL), which is a specific portion of an alpha helical region of human c-myc protein. This MAb shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Overexpression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.
Image Unavailable-75921-012

Anti-MYC Mouse Monoclonal Antibody (Biotin) [clone: 9E10.]

Supplier: Biotium
Description: This antibody recognizes a transcription factor of 64-67 kDa, identified as c-myc. Its epitope spans aa 410-419 (EQKLISEEDL), which is a specific portion of an alpha helical region of human c-myc protein. This MAb shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Overexpression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.

Product Image-10348-492

Anti-KL Rabbit Polyclonal Antibody

Catalog Number: (10348-492)
Supplier: Bioss
Description: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Image Unavailable-10404-968

Anti-ANXA7 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10404-968)
Supplier: Bioss
Description: The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A7 is a member of the annexin family of calcium dependent phospholipid binding proteins. The Annexin A7 gene contains 14 exons and spans approximately 34 kb of DNA. Structural analysis of the protein suggests that Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion.
Image Unavailable-89329-716

Anti-CD20 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: LT20]

Catalog Number: (89329-716)
Supplier: Genetex
Description: Clone: LT20 Conjugation: FITC Purity: Protein A purified Species Reactivity: Human Tested Applications: FACS Pkg Size: 100 test
Image Unavailable-89278-310

Anti-CD20 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: 2H7]

Catalog Number: (89278-310)
Supplier: Genetex
Description: Mouse monoclonal antibody [2H7] to CD20
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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