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Product Image-77750-024

Human Recombinant BDNF (from E. coli)

Description: <p>Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival.  BDNF expression in the hippocampus is essential for long-term memory storage and learning.  Human, mouse, rat, and pig BDNF are cross-reactive.</p>
Catalog Number: 77750-024
Supplier: VWR International

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Product Image-77750-272

Human Recombinant I-TAC (from E. coli)

Description: Interferon-inducible T cell alpha chemoattractant (I-TAC), or CXCL11, is expressed at high levels in leukocytes, pancreas, and liver cells. I-TAC gene expression is induced by interferons alpha (IFN-α), beta (IFN-β), and gamma (IFN-ɣ). I-TAC is the dominant ligand known to bind the chemokine receptor CXCR3, thus acting as a stronge agonist. I-TAC functions as a chemoattractant for interleukin 2 (IL-2)-activated T cells.
Catalog Number: 77750-272
Supplier: VWR International

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Product Image-77752-470

Mouse Recombinant SHH (from E. coli)

Description: Sonic hedgehog (SHH) is a member of a small group of hedgehog secreted proteins that are essential for development in both vertebrates and invertebrates. There are three mammalian hedgehog homologues, sonic, desert, and indian, that signal via the Patched-1 and Patched-2 receptors. SHH is a morphogen that is essential during vertebrate organogenesis and adult stem cell division.
Catalog Number: 77752-470
Supplier: VWR International

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Product Image-77752-198

Mouse Recombinant LEPTIN (from E. coli cells)

Description: Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage.
Catalog Number: 77752-198
Supplier: VWR International

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Product Image-77752-148

Mouse Recombinant IL-5 (from E. coli)

Description: Interleukin 5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. IL-5 expression is regulated by the GATA binding protein 3 (GATA3) transcription factor. Human and mouse IL-5 show cross-reactivity.
Catalog Number: 77752-148
Supplier: VWR International

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Product Image-77751-942

Mouse Recombinant IGF-I (from E. coli)

Description: Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.
Catalog Number: 77751-942
Supplier: VWR International

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Product Image-77751-828

Human Recombinant IL-19 (from E. coli cells)

Description: Interleukin-19 (IL-19) is a member of the interleukin 10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin 20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-a) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses.
Catalog Number: 77751-828
Supplier: VWR International

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Product Image-77751-004

Human Recombinant SDF-1 A/CXCL12 (from E. coli cells)

Description: Stromal cell-derived factor-1 alpha (SDF-1 α), also called CXCL12a, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulation by inflammatory cytokines such as TNF, IL-1, and LPS. SDF-1α signals through the G protein-coupled receptor CXCR4 to recruit activated leukocytes. Human and mouse SDF-1 α share 99% sequence identity.
Catalog Number: 77751-004
Supplier: VWR International

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Product Image-77750-326

Human Recombinant MIP-1 B (from E. coli)

Description: Macrophage inflammatory protein-1 beta (MIP-1 β), also known as CCL4, is  produced by macrophages and functions as a mitogen-inducible cytokine.  MIP-1 β signals through the chemokine receptor CCR5 to chemoattract immune cells.  MIP-1 β induces inflammatory responses, including neutrophil superoxide production.  The MIP-1 β and MIP-1 α heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1). 
Catalog Number: 77750-326
Supplier: VWR International

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Product Image-77752-888

Rat Recombinant GDNF (from E. coli)

Description: Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.
Catalog Number: 77752-888
Supplier: VWR International

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Product Image-77751-732

Human Recombinant PSP (from E. coli cells)

Description: Persephin is a neurotrophic factor of the glial cell line-derived neurotrophic factor (GDNF) family. Persephin promotes survival and growth of dopaminergic and motor neurons, but not peripheral neurons. Persephin is a ligand for the RET receptor tyrosine kinase.
Catalog Number: 77751-732
Supplier: VWR International

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Product Image-77750-528

Human Recombinant GALECTIN-3 (from E. coli)

Description: Galectin-3 belongs to the lectin family of carbohydrate binding proteins. Galectin-3 is expressed by a wide range of cell types including activated T cells, tumor cells, macrophages, osteoclasts, fibroblasts, and epithelial cells. Galectin-3 has specific binding affinity for beta-galactoside sugar moieties and has functional roles during development, innate immunity, cell apoptosis, and tumor metastasis.
Catalog Number: 77750-528
Supplier: VWR International

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Product Image-77753-286

Pig Recombinant IL-2 (from E. coli cells)

Description: Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.
Catalog Number: 77753-286
Supplier: VWR International

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Product Image-77753-222

Dog Recombinant IL-2 (from E. coli)

Description: Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.  
Catalog Number: 77753-222
Supplier: VWR International

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Product Image-77752-972

Rat Recombinant FGF-9 (from E. coli)

Description: Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination.
Catalog Number: 77752-972
Supplier: VWR International

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Product Image-77750-216

Human Recombinant VEGF-121 (from E. coli)

Description: <p>Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways.</p>
Catalog Number: 77750-216
Supplier: VWR International

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