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Product Image-77750-932

Human Recombinant IL-1RA (from E. coli cells)

Description: Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation.
Catalog Number: 77750-932
Supplier: VWR International

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Product Image-77750-306

Human Recombinant MCP-1 (from E. coli)

Description: <p>Monocyte chemotactic protein 1 (MCP-1), also known as CCL2, is produced by injured or infected tissues. MCP-1 signals through the CCR2 and CCR4 G protein-coupled receptors to recruit memory T cells, monocytes, and dendritic cells to sites of inflammation.</p>
Catalog Number: 77750-306
Supplier: VWR International

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Product Image-77751-876

Mouse Recombinant IL-3 (from E. coli)

Description: Interleukin 3 (IL-3) is a cytokine that is produced by activated T cells and mast cells.  IL-3 induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells.  IL-3 also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases.  
Catalog Number: 77751-876
Supplier: VWR International

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Product Image-77750-066

Human Recombinant SCF (from E. coli)

Description: Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.
Catalog Number: 77750-066
Supplier: VWR International

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Product Image-77751-392

Human Recombinant TNFR-1 (from E. coli)

Description: Tumor necrosis factor receptor type 1 (TNFR-1) is expressed in most tissues and is activated by soluble and membrane-bound tumor necrosis factor alpha (TNF-α). TNFR-1 activates NF-κB and MAPK pathways to induce inflammation, promote apoptotic cell death, inhibit tumorigenesis, and inhibit viral replication.
Catalog Number: 77751-392
Supplier: VWR International

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Product Image-77752-706

Mouse Recombinant IL-36 G (from E. coli)

Description: Interleukin 36 gamma (IL-36 ɣ) is a member of the interleukin 1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36 ɣ binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
Catalog Number: 77752-706
Supplier: VWR International

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Product Image-77752-336

Mouse Recombinant IP-10 (from E. coli)

Description: Interferon gamma-induced protein 10 (IP-10), or CXCL10, is a chemokine secreted by monocytes, endothelial cells, and fibroblasts in response to interferon gamma (IFN-γ).  IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and natural killer (NK) cells that express the G protein-coupled receptor CXCR3.  IP-10 is an important factor in autoimmune diseases such as Hashimoto's thyroiditis, Graves' disease, and Type 1 diabetes mellitus. 
Catalog Number: 77752-336
Supplier: VWR International

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Product Image-77750-330

Human Recombinant MIP-3 B CCL19 (from E. coli)

Description: <p>Macrophage inflammatory protein-3 beta (MIP-3 β), also called CCL19, is a chemokine that is expressed in the thymus, lymph nodes, and activated bone marrow stromal cells. MIP-3 β signals through the G protein-coupled receptor CCR7 to regulate normal lymphocyte recirculation. MIP-3 β also functions during T cell trafficking to the thymus, and in T cell and B cell homing to the lymph nodes and secondary lymphoid organs. Human MIP-3 β shows activity on mouse cells.</p>
Catalog Number: 77750-330
Supplier: VWR International

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Product Image-77752-142

Mouse Recombinant IL-5 (from E. coli)

Description: Interleukin 5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. IL-5 expression is regulated by the GATA binding protein 3 (GATA3) transcription factor. Human and mouse IL-5 show cross-reactivity.
Catalog Number: 77752-142
Supplier: VWR International

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Product Image-77750-358

Human Recombinant Rantes (from E. coli)

Description: <p>Regulated upon activation, normal T cell expressed and secreted (RANTES), also called CCL5, is a chemokine produced by T cells three to five days after T cell activation. Rantes signals through G protein-coupled receptors CCR5, CCR3, CCR1, and through the human CMV-encoded viral receptor US28. Rantes functions to recruit immune cells to inflammatory sites.</p>
Catalog Number: 77750-358
Supplier: VWR International

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Product Image-77750-278

Human Recombinant IL-2 (from E. coli)

Description: Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.
Catalog Number: 77750-278
Supplier: VWR International

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Product Image-77750-304

Human Recombinant MCP-3 (from E. coli)

Description: Monocyte chemotactic protein 3 (MCP-3), also called CCL7, is produced by macrophages and tumor cell lines. MCP-3 signals through the G protein-coupled receptors CCR1, CCR2, and CCR3. MCP-3 chemoattracts monocytes and regulates macrophage function during inflammation and metastasis.
Catalog Number: 77750-304
Supplier: VWR International

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Product Image-77750-890

Human Recombinant IL-5 (from E. coli)

Description: Interleukin 5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. Human and mouse IL-5 show cross-reactivity.
Catalog Number: 77750-890
Supplier: VWR International

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Product Image-77751-918

Mouse Recombinant IL-7 (from E. coli)

Description: Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes.
Catalog Number: 77751-918
Supplier: VWR International

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Product Image-77750-110

Human Recombinant GM-CSF (from E. coli cells)

Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is hematopoietic growth factor produced by endothelial cells, monocytes, fibroblasts, and T cells. GM-CSF stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells.
Catalog Number: 77750-110
Supplier: VWR International

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Product Image-77752-092

Mouse Recombinant IFN-G (from E. coli)

Description: Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation.
Catalog Number: 77752-092
Supplier: VWR International

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