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Anti-ALKBH2 Rabbit Polyclonal Antibody

Catalog Number: (10751-036)

Supplier: Prosci

Description: ALKBH2 Antibody: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.

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Copper(II) nitrate hemipentahydrate 98.0-102.0% ACS

Supplier: Thermo Scientific Chemicals

Description: Catalyst, nitrating agent for aromatic organosilicon compounds, nickel-plating baths, coloring copper black, and producing a burnished effect on iron

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Anti-ALKBH2 Rabbit Polyclonal Antibody

Catalog Number: (10799-964)

Supplier: Rockland Immunochemical

Description: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.

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Nickel boride ≥99% (metals basis)

Catalog Number: (AA13110-22)

Supplier: Thermo Scientific Chemicals

Description: 99% (metals basis).-35 Mesh Granular,DANGER: Cancer risk, irritates skin, eyes & mucous membranes,25g,100g.

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Accessories for Power-Stir® High-Torque Overhead Stirrer, Eberbach

Supplier: Eberbach

Description: Agitator — Stainless steel blades are riveted onto 6.3 mm (<sup>1</sup>/<sub>4</sub>") shafts. Pitch of blade can be varied to control degree of agitation. Creates downward thrust when rotated in clockwise direction. The 46 cm (18") and 61 cm (24") shaft lengths are recommended for hollow spindle stirrers.