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Description: The PD-1 Antibody (913425) [Phycoerythrin] from Novus Biologicals is a mouse monoclonal antibody to PD-1. This antibody reacts with human. The PD-1 Antibody (913425) [Phycoerythrin] has been validated for the following applications: Flow Cytometry.
Catalog Number: 103294-464
Supplier: Novus Biologicals


Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167 UN No: UN1325; Haz Class: 4.1; Packing Group: III Powder; Molecular Formula: Pd; MW: 106.42 Melting Point: 1555°; Boiling Point: 2963°
Catalog Number: BT221570-5G
Supplier: BeanTown Chemical

SDS


Description: The PD-1 Antibody (J43) [Allophycocyanin] from Novus Biologicals is a armenian hamster monoclonal antibody to PD-1. This antibody reacts with mouse. The PD-1 Antibody (J43) [Allophycocyanin] has been validated for the following applications: Flow Cytometry.
Catalog Number: 103407-210
Supplier: Novus Biologicals


Description: Programmed cell death 1 ligand 2 (PD-L2), also known as butyrophilin B7-DC or PDCD1 ligand 2, belongs to the member of B7 family which can regulate the activation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1), and the other is PD-L1. These two ligands shares 34% aa sequence identity. Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide, a 201 aa extracellular region , a 21 aa transmembrane domain and a 32 aa cytoplasmic region. The mouse PD-L2 gene is highly expressed in heart, placenta, pancreas, lung and liver while expressed weakly in spleen, lymph nodes and thymus. Besides, the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment, and up-regulated by IFNG/IFN-gamma stimulation in monocytes. PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expression of PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.
Catalog Number: 75791-564
Supplier: Prosci


Description: Rat PD-L1 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of rat PD-L1 in serum, plasma, tissue homogenates, and other biological fluids.
Catalog Number: 76746-674
Supplier: ANTIBODIES.COM LLC


Description: PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.
Catalog Number: 76163-714
Supplier: Prosci


Description: PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.
Catalog Number: 76163-708
Supplier: Prosci


Description: PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.
Catalog Number: 76163-710
Supplier: Prosci


Description: PD-L1/B7-H1 Protein (HPLC-verified), Host: HEK293, Species Reactivity: Human, Purity: >98%, Molecular Characterization: fused with a polyhistidine tag at the C-terminus, MW of 26 kDa, Synonym: PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1, Storage: 4 deg C, Size: 1mg
Catalog Number: 103015-174
Supplier: ACROBIOSYSTEMS INC MS


Description: Methanesulfonato[1,1'-bis(diphenylphosphino)ferrocene)](2'-amino-1,1'-biphenyl-2-yl)palladium(II) 98%
Catalog Number: 77567-466
Supplier: Ambeed

New Product


Description: Recombinant Human PD-L1 Fc, Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses, Source: CHO cells, Determined by its ability to induce adhesion in T-cell enriched PBMC cultures, Synonyms: Programmed Death Ligand 1, PD-1, B7-H1, SLEB2, SLE1, Size: 1MG
Catalog Number: 75999-598
Supplier: Peprotech


Description: MorDalPhos Pd G4 ≥98%
Catalog Number: 77783-423
Supplier: Ambeed

New Product


Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167; RTECS: RT3480500 Solid; Molecular Formula: Pd; MW: 106.42 Melting Point: 1554°; Boiling Point: 2970° Density (g/mL): 12.02
Catalog Number: BT217645-25X25
Supplier: BeanTown Chemical

SDS


Description: The PD-1 Antibody (913425) [Biotin] from Novus Biologicals is a mouse monoclonal antibody to PD-1. This antibody reacts with human. The PD-1 Antibody (913425) [Biotin] has been validated for the following applications: Flow Cytometry.
Catalog Number: 103294-698
Supplier: Novus Biologicals


Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Catalog Number: 75791-904
Supplier: Prosci


Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Catalog Number: 75791-760
Supplier: Prosci


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