You Searched For: PD-161570

Catalog Number: (10051-708)

Supplier: Tonbo Biosciences

Description: The 10F.9G2 antibody is specific for mouse CD274, more commonly known as PD-L1 or B7-H1, which acts as a ligand for the T cell co-regulatory receptor PD-1 (CD279). This interaction modulates T cell antigen receptor (TCR) signaling and therefore T cell activation. PD-L1 binding to PD-1 expressed on CD4- CD8- thymocytes participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-L1 may also bind PD-1 following the receptor’s inducible expression on activated, mature T cells, where it has been proposed to limit T cell activation. PD-L1 is one of a group of “B7” ligands whose interactions with the CD28 receptor family, also including CTLA-4 (CD152), provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.

Catalog Number: (ABCA_AB224027-100U)

Supplier: Abcam

Description: FITC Rabbit monoclonal [28-8] to PD-L1.

New Product

Catalog Number: (103885-888)

Supplier: Sino Biological

Description: A DNA sequence encoding the human CD274 (NP_054862.1) (Met1-Arg238) was expressed.

Supplier: Abcam

Description: Alexa Fluor® 555 Rabbit monoclonal [CAL10] to PD-L1.

New Product

Catalog Number: (10765-104)

Supplier: Prosci

Description: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00011167

SDS Certificates

Catalog Number: (ABCA_AB236119-1MG)

Supplier: Abcam

Description: Rabbit monoclonal [EP12357] to Prostaglandin D Synthase (Lipocalin)/PDS - BSA and Azide free.

New Product

Supplier: Abcam

Description: Mouse monoclonal [CAL10] to PD-L1 - Chimeric – BSA and Azide free.

New Product

Supplier: Strem Chemicals Inc

Description: CAS #: 7440-05-3. Size: 50g.

Supplier: Strem Chemicals Inc

Description: Escat

Supplier: ACROBIOSYSTEMS INC MS

Description: Mouse Recombinant PD-L1 (from HEK293)

Catalog Number: (220022-821)

Supplier: R&D Systems

Description: The Recombinant Human PD-L2/B7-DC Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Human PD-L2/B7-DC Fc Chimera Protein has been validated for the following applications: Binding Activity.

Supplier: Bio X Cell

Description: InVivoPlus rat IgG1 isotype control, Clone: TNP6A7, Isotype: rat IgG1, λ, Applications: in vivo blocking of PD-1/PD-L signaling, in vitro PD-1 neutralization, Immunohistochemistry (frozen), Flow cytometry, Western blot

Supplier: Abcam

Description: Rabbit recombinant multiclonal [RM1012] to PD-L1 - BSA and Azide free.

New Product

Catalog Number: (102099-832)

Supplier: Electron Microscopy Sciences

Description: Metal sputtering targets are made from high purity metals, starting 99.99% with most standard disc sizes, for use on most sputtering units from many manufacturers: Emitech, Emscope, Bio-Rad, Polaron, Edwards, Balzers, Plasma Sciences, Technics Hummers, Denton, Cressington, and much more.

Supplier: Strem Chemicals Inc

Description: CAS #: 7440-05-3. Size: 100mm.