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Description: PD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Catalog Number: 10749-174
Supplier: Prosci


Description: Tetrakis(triphenylphosphine)palladium(0) 99.9% (trace metals basis)
Catalog Number: TS44140-0010
Supplier: Thermo Scientific Chemicals


Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167; RTECS: RT3480500 UN No: UN3089; Haz Class: 4.1; Packing Group: III Powder; Molecular Formula: Pd; MW: 106.42 Melting Point: 1554°; Boiling Point: 2970° Density (g/mL): 12.02
Catalog Number: BT145940-5G
Supplier: BeanTown Chemical

SDS


Description: CAS Number: 31277-98-2
MDL Number: MFCD00009880
Molecular Formula: C52H48P4Pd
Molecular Weight: 903.27
Purity/Analysis Method: >96.0% (T)
Form: Crystal
Storage Temperature: >-20°C
Catalog Number: TCB3224-1G
Supplier: TCI America

SDS


Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167; RTECS: RT3480500 UN No: UN3089; Haz Class: 4.1; Packing Group: II Powder; Molecular Formula: Pd; MW: 106.42 Melting Point: 1554°; Boiling Point: 2970° Density (g/mL): 12.02
Catalog Number: BT129065-1G
Supplier: BeanTown Chemical

SDS


Description: MDL: MFCD00015959
Catalog Number: AA11042-09
Supplier: Thermo Scientific Chemicals

Description: The Recombinant Human PD-1 His Tagged Protein from R&D Systems is derived from HEK293. The Recombinant Human PD-1 His Tagged Protein has been validated for the following applications: Bioactivity.
Catalog Number: MSPP-8986PD100
Supplier: R&D Systems


Description: Mouse PD-L1 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of mouse PD-L1 in serum, plasma, and other biological fluids.
Catalog Number: 77174-238
Supplier: ANTIBODIES.COM LLC


Description: MDL: MFCD00011169 Soluble in water with turbidity, precipitating a brown basic salt. Completely soluble in dilute HNO3
Catalog Number: AA11035-18
Supplier: Thermo Scientific Chemicals

Description: Produced in HEK cells. Human PD-L1 (aa 19-239) is fused at the N-terminus to a His-tag and FLAG®-tag.
Catalog Number: 76202-250
Supplier: Enzo Life Sciences


Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Catalog Number: 75791-904
Supplier: Prosci


Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Catalog Number: 75791-760
Supplier: Prosci


Description: CAS: 12135-22-7; EC No: 235-219-2; MDL No: MFCD00064599 Powder; Linear Formula: Pd(OH)2; MW: 140.42
Catalog Number: BT140370-250MG
Supplier: BeanTown Chemical

SDS


Description: CAS #: 14852-83-6. Size: 5g.
Catalog Number: 100198-820
Supplier: Strem Chemicals Inc


Description: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.
Catalog Number: 76163-632
Supplier: Prosci


Description: The product is specific for human PD-1 (UniProt Accession: Q15116). This antibody blocks human PD-L1 binding with human PD-1 expression cell line in flow cytometry assay.
Catalog Number: 76198-898
Supplier: Genscript


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