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Image Unavailable-10301-066

Anti-NOSTRIN Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10301-066)
Supplier: Bioss
Description: NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.
Image Unavailable-76170-988

Anti-NOS2 IgG Polyclonal Antibody

Catalog Number: (76170-988)
Supplier: Boster Biological Technology
Description: Rabbit IgG polyclonal antibody for Nitric oxide synthase, inducible(NOS2) detection. Tested with WB in Human.
Image Unavailable-102516-256

GYY 4137 ≥95% (by NMR)

Supplier: Adipogen
Description: Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Exhibits vasodilator and antihypertensive activity. Anti-inflammatory. Inhibits LPS-induced release of proinflammatory mediators (IL-1beta, IL-6, TNF-alpha, nitric oxide (NO) and PGE2) and increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-kappaB, ATF-2 and HSP27 dependent pathways. Causes stomatal opening and reduces nitric oxide accumulation in plants. Oxidative stress-induced cell death inhibitor. Shows novel anti-cancer effects in vitro and in vivo. Anti-thrombotic via p-selectin dependent mechanism.

Small Business Enterprise

Image Unavailable-AAJ61316-MF

Carboxy-PTIO potassium salt ≥98%

Supplier: Thermo Scientific Chemicals
Description: Stable, water-soluble free radical that reacts with nitric oxide (NO) to inhibit NO synthase

SDS Certificates

Product Image-10103-126

Anti-GUCY1B3 Rabbit Polyclonal Antibody

Catalog Number: (10103-126)
Supplier: Prosci
Description: Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).
Image Unavailable-80600-352

DAR-4M AM (cell permeable) ≥98% (by HPLC), Calbiochem®, Sigma-Aldrich®

Catalog Number: (80600-352)
Supplier: MilliporeSigma
Description: A cell-permeable, photo-stable nitric oxide (NO) fluorescent indicator with a detection limit of ~10 nM.

Certificates


Image Unavailable-IC19032605

Chlorpromazine hydrochloride

Supplier: MP Biomedicals
Description: Chlorpromazine Hydrochloride is a phenothiazine antipsychotic; a D2 and H1 antagonist. It inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase and is reported to uncouple and inhibit oxidative phosphorylation at 10-3 - 10-4 M. It is possibly a photogenotoxic agent in humans. Helps to induce hypothermia in mice in the dose range of 12.5 -100 mg/kg.
Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Image Unavailable-80058-662

Spermidine trihydrochloride ≥99%, Calbiochem®

Catalog Number: (80058-662)
Supplier: MilliporeSigma
Description: Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Inhibits neuronal nitric oxide synthase.

SDS Certificates


Image Unavailable-89298-176

Anti-CAPON / NOS1AP (nitric oxide Synthase 1 (neuronal) adaptor Protein) Goat Polyclonal Antibody

Catalog Number: (89298-176)
Supplier: Genetex
Description: Goat polyclonal antibody to CAPON / NOS1AP
Image Unavailable-102981-232

DAR-4T ≥98% (by NMR)

Supplier: Adipogen
Description: Reference compound for the fluorescent (nitric oxide) NO probe DAR-4.

Image Unavailable-10336-434

Anti-NOS2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10336-434)
Supplier: Bioss
Description: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Image Unavailable-10301-054

Anti-NOSTRIN Rabbit Polyclonal Antibody

Catalog Number: (10301-054)
Supplier: Bioss
Description: NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.
Image Unavailable-10302-652

Anti-NOSTRIN Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10302-652)
Supplier: Bioss
Description: NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.
Image Unavailable-89304-846

Anti-nNOS (nitric oxide Synthase 1 (neuronal)) Rabbit Polyclonal Antibody

Catalog Number: (89304-846)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to nNOS
Image Unavailable-102971-776

Apelin 12

Catalog Number: (102971-776)
Supplier: Anaspec Inc
Description: Apelin-12, one of the most potent apelin peptides, lowers blood pressure via a nitric oxide-dependent mechanism. It is also involved in the central control of feeding by stimulating cholecystokinin (CCK) secretion.
Sequence:RPRLSHKGPMPF
MW:1422.7 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C
Image Unavailable-102987-206

Wogonin ≥98% (by HPLC)

Supplier: Adipogen
Description: Anti-inflammatory. Increases nitric oxide (NO) production. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II). Antioxidant. Anti-viral. Shows anti-hepatitis B virus activity. MCP-1 inhibitor. Shows anxiolytic effect through modulation of the GABA(A) receptor complex. Antifungal. Neuroprotective. Anticancer compound. Apoptosis and cell cycle arrest inducer. Sensitizes TNFalpha- and TRAIL-induced apoptosis. Antiangiogenic. NF-kappaB inhibitor. Telomerase activity inhibitor. CDK9 inhibitor. PI3K-AKT pathway modulator. Autophagy inducer.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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