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Product Image-10787-202

Human Recombinant VEGF-121 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with one being VEGF-121. The VEGF-121 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell function.

Product Image-RCMMPD10KN-50

Palladium(II) nitrate (1.0% Pd) in nitric acid 5% matrix modifier solution

Catalog Number: (RCMMPD10KN-50)
Supplier: Ricca Chemical
Description: 1.0% Palladium. Used to support Inductively coupled plasma (ICP) analysis to sharpen the contrast and improve the readability. 50mL.

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Product Image-13453-412

Short-Term Detector Tubes, Draeger

Supplier: Draeger
Description: Short-Term detector tubes for use with the accuro® Gas Detector Pump and Aerotest Breathing Air Tester.

Product Image-13453-296

Short-Term Detector Tubes, Draeger

Supplier: Draeger
Description: For use with the accuro® Gas Detector Pump (see 34330-068 series) and Aerotest Breathing Air Tester (see 34330-078).

Image Unavailable-102987-734

2,3-Diaminonaphthalene

Supplier: Adipogen
Description: The 2,3-diaminonaphthalene (DAN) assay is routinely used in the determination of nitrite/nitrate levels in biological fluids and cellular extracts as one indicator of nitric oxide activity. The assay, as reported by Misko, uses the reaction of DAN with NO2- under acidic conditions to form a detectable fluorescent naphthotriazole. The reaction proceeds at acidic pH at room temperature. Fluorescence is monitored following the addition of NaOH, which raises pH, resulting in lower background and increased sensitivity (Ex/Em: ~365/415nm). However, detection at 450nm is recommended to avoid fluorescent blanks and increase sensitivity. The fluorescent background of DAN is low for maximum sensitivity. Detection limits of NO achieved by this method are in the high-pM range. 2,3-Diaminonaphtaline (DAN) is used as a derivatisation-reagent for the determination of selenium at low detection limits. The 4,5-benzopiaselenol-complex can be quantified by photometry or GC.

Product Image-10787-604

Human Recombinant VEGF-165 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.

Image Unavailable-RL009-001-B99

Human Recombinant VEGFA (from E. coli)

Catalog Number: (RL009-001-B99)
Supplier: Rockland Immunochemical
Description: Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as Tumor Angiogenesis Factor or Vascular Permeability Factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating vasolidation via nitric oxide-dependent pathways. Alternative splicing of the mRNA for VEGF-A results in several isoforms of the protein being produced. Rat and bovine VEGF are one amino acid shorter than the human factor, and the bovine and human sequences show a homology of 95 percent.

In contrast to other factors mitogenic for endothelial cells such as FGF-1, FGF-2 and PDGF, VEGF is synthesized as a precursor containing a typical hydrophobic secretory signal sequence of 26 amino acids. Glycosylation is not required for efficient secretion of VEGF. Recombinant Human VEGF produced in E.coli is a double, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 38231 Daltons.

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Product Image-77697-697

Pre-Mixed GFAA matrix modifier 2: 1000 µg/mL Pd & 600 µg/mL Mg(NO3)2 (w/v) in nitric acid 2%, certified reference material, VHG

Catalog Number: (77697-697)
Supplier: LGC Standards
Description: This Palladium & Magnesium Nitrate solution is intended for use as a matrix modifier CRM for graphite furnace atomic absorption spectroscopy (GFAA).

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Product Image-TS45854-1000

Millon's reagent for the detection of tyrosine

Supplier: Thermo Scientific Chemicals
Description: Millon's reagent for the detection of tyrosine

Product Image-77697-696

Pre-Mixed GFAA matrix modifier 1: 750 µg/mL Pd & 500 µg/mL Mg(NO3)2 (w/v) in nitric acid 2%, certified reference material, VHG

Catalog Number: (77697-696)
Supplier: LGC Standards
Description: This Palladium & Magnesium Nitrate solution is intended for use as a matrix modifier CRM for graphite furnace atomic absorption spectroscopy (GFAA).

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Product Image-10788-502

Rat Recombinant IL-17F (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.

Image Unavailable-IC10047201

Spermidine trihydrochloride ≥99%, crystalline

Supplier: MP Biomedicals
Description: Spermidine is a biogenic polyamine formed from putrescine. It is essential in both normal and neoplastic tissue growth. It plays an important role in the regulation of cellular proliferation and differentiation. Forms stable compounds with nucleic acids. Inhibits neuronal nitric oxide synthase (nNOS).

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Product Image-76057-728

CONSTIX®, Sealed Polyester Swabs, SP-11 Series, Contec®

Catalog Number: (76057-728)
Supplier: Contec
Description: CONSTIX® SP-11 sealed polyester swabs consist of 100% knitted polyester fabric that is thermally bonded to a rigid polypropylene handle.

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Product Image-89145-450

Anti-OPN Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences
Description: Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

Product Image-76062-538

Anti-NOSIP Rabbit Polyclonal Antibody

Catalog Number: (76062-538)
Supplier: Prosci
Description: For WB starting dilution is: 1:1000
Image Unavailable-75790-594

Human Recombinant EDF1 (from E. coli)

Catalog Number: (75790-594)
Supplier: Prosci
Description: Endothelial Differentiation-Related Factor 1 (EDF1) is a 148 amino acid transcriptional coactivator that contains 1 HTH cro/C1-type DNA-binding domain. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. When endothelial cells are induced to differentiate in vitro, EDF1 is downregulated, leading to inhibition of cell growth and cell polarization. EDF1 binds calmodulin thorough its IQ domain and regulates nitric oxide synthase activity through calmodulin sequestration in the cytoplasm. Though ubiquitously expressed, EDF1 is most abundant in adult liver, heart, adipose tissues, intestine and pancreas. In fetal tissues, EDF1 is most abundant in kidney. There are two isoforms of EDF1 that are produced as a result of alternative splicing events.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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