You Searched For: N-(1,1,3,3-Tetramethylbutyl)acrylamide

Catalog Number: (TCB0978-025ML)

Supplier: TCI America

Description: CAS Number: 2362-10-9
MDL Number: MFCD00000877
Molecular Formula: C6H16Cl2OSi2
Molecular Weight: 231.26
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Boiling point (°C): 204
Flash Point (°C): 73
Specific Gravity (20/20): 1.05

SDS

Supplier: Enzo Life Sciences

Description: AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

Supplier: Adipogen

Description: AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the nanomolar range with over 100-fold selectivity compared with other kinases, apart from ABL and FLT1, which were both moderately sensitive to the compound. In cells, AV-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-dependent cell proliferation with an IC(50) of 100nM. Moreover, AV-412 abrogated EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR. In animal studies using cancer xenograft models, AV-412 (30mg/kg) demonstrated complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.

Supplier: MP Biomedicals

Description: N,N,N',N'-Tetramethylethylenediamin is a tertiary amine base.

SDS

Catalog Number: (77995-029)

Supplier: LGC Standards

Description: TRC Tyloxapol

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Supplier: LGC Standards

Description: TRC Benzethonium Chloride

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Catalog Number: (77692-958)

Supplier: LGC Standards

Description: Organic Standard, Benzethonium Chloride

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Supplier: LGC Standards

Description: TRC Bis(4-Tert-octylphenyl)amine (>85%)

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Catalog Number: (77990-797)

Supplier: LGC Standards

Description: TRC 4-tert-Octylphenol Diethoxylate-13C6

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Supplier: LGC Standards

Description: TRC 2-Benzotriazolyl-4-tert-octylphenol

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Supplier: LGC Standards

Description: TRC 4-tert-Octylphenol Monoethoxylate

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Supplier: LGC Standards

Description: TRC 2-Benzotriazolyl-4-tert-octylphenol-13C6

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Catalog Number: (77976-944)

Supplier: LGC Standards

Description: TRC Alkylated Diphenylamines

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Catalog Number: (77994-918)

Supplier: LGC Standards

Description: TRC Triton X-100

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Supplier: Spectrum Chemicals

Description: Tyloxapol is a liquid polymer that is nonionic and of the alkyl aryl polyether type. Tyloxapol is used as a surfactant, detergent, dispersing agent, encapsulating agent and hydroxy radical scavenger. It is a non-ionic liquid polymer that is soluble in polar and non-polar solvents.

Certificates

Catalog Number: (77994-060)

Supplier: LGC Standards

Description: TRC Tetraethylthiourea

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