You Searched For: N-(1,1,3,3-Tetramethylbutyl)acrylamide


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Catalog Number: (TCB0978-025ML)
Supplier: TCI America
Description: CAS Number: 2362-10-9
MDL Number: MFCD00000877
Molecular Formula: C6H16Cl2OSi2
Molecular Weight: 231.26
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Boiling point (°C): 204
Flash Point (°C): 73
Specific Gravity (20/20): 1.05

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Supplier: Enzo Life Sciences
Description: AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

Supplier: Adipogen
Description: AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the nanomolar range with over 100-fold selectivity compared with other kinases, apart from ABL and FLT1, which were both moderately sensitive to the compound. In cells, AV-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-dependent cell proliferation with an IC(50) of 100nM. Moreover, AV-412 abrogated EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR. In animal studies using cancer xenograft models, AV-412 (30mg/kg) demonstrated complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.

Supplier: MP Biomedicals
Description: N,N,N',N'-Tetramethylethylenediamin is a tertiary amine base.

SDS

Catalog Number: (77995-029)
Supplier: LGC Standards
Description: TRC Tyloxapol

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Catalog Number: (77692-958)
Supplier: LGC Standards
Description: Organic Standard, Benzethonium Chloride

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Supplier: LGC Standards
Description: TRC Benzethonium Chloride

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Supplier: LGC Standards
Description: TRC Bis(4-Tert-octylphenyl)amine (>85%)

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Catalog Number: (77990-797)
Supplier: LGC Standards
Description: TRC 4-tert-Octylphenol Diethoxylate-13C6

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Supplier: LGC Standards
Description: TRC 2-Benzotriazolyl-4-tert-octylphenol

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Supplier: LGC Standards
Description: TRC 4-tert-Octylphenol Monoethoxylate

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Supplier: LGC Standards
Description: TRC 2-Benzotriazolyl-4-tert-octylphenol-13C6

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Catalog Number: (77976-944)
Supplier: LGC Standards
Description: TRC Alkylated Diphenylamines

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Catalog Number: (77994-918)
Supplier: LGC Standards
Description: TRC Triton X-100

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Supplier: Spectrum Chemicals
Description: Tyloxapol is a liquid polymer that is nonionic and of the alkyl aryl polyether type. Tyloxapol is used as a surfactant, detergent, dispersing agent, encapsulating agent and hydroxy radical scavenger. It is a non-ionic liquid polymer that is soluble in polar and non-polar solvents.
Catalog Number: (77994-060)
Supplier: LGC Standards
Description: TRC Tetraethylthiourea

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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