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Image Unavailable-100243-030

Anti-CD106 Rat Monoclonal Antibody [clone: M/K-2]

Catalog Number: (100243-030)
Supplier: Southern Biotechnology
Description: CD106, also known as VCAM-1, is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (e.g., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein. The M/K-2 monoclonal antibody immunoprecipitates a peptide that gives a single band on SDS-PAGE gels with an apparent Mr of ~100 kDa under reducing conditions and 92 kDa under non-reducing conditions.
Image Unavailable-80058-404

MK-886 5MG

Catalog Number: (80058-404)
Supplier: MilliporeSigma
Description: MK-886 5MG

Certificates


Image Unavailable-77974-312

MK-886 5G

Catalog Number: (77974-312)
Supplier: FUJIFILM IRVINE SCIENTIFIC WAKO CHE
Description: MK-886 5G

New Product


Image Unavailable-ABCA_AB147242-50MG

MK-1775 AB147242-50MG

Catalog Number: (ABCA_AB147242-50MG)
Supplier: Abcam
Description: MK-1775 AB147242-50MG

New Product


Image Unavailable-100505-208

(-)-MK 801 MALEATE 10MG

Catalog Number: (100505-208)
Supplier: R&D Systems
Description: (-)-MK 801 MALEATE 10MG
Image Unavailable-100506-996

(+)-MK 801 MALEATE 50MG

Catalog Number: (100506-996)
Supplier: R&D Systems
Description: (+)-MK 801 MALEATE 50MG
Image Unavailable-102870-828

MK 571 (10 MG)

Catalog Number: (102870-828)
Supplier: R&D Systems
Description: MK 571 (10 MG)
Image Unavailable-102658-480

MK 801 3H 1 MCI

Catalog Number: (102658-480)
Supplier: American Radiolabeled Chemicals
Description: MK 801 3H 1 MCI
Image Unavailable-ABCA_AB147242-5MG

MK-1775 AB147242-5MG

Catalog Number: (ABCA_AB147242-5MG)
Supplier: Abcam
Description: MK-1775 AB147242-5MG

New Product


Image Unavailable-ABCA_AB286988-5MG

MK-7655 AB286988-5MG

Catalog Number: (ABCA_AB286988-5MG)
Supplier: Abcam
Description: MK-7655 AB286988-5MG

New Product


Image Unavailable-100505-630

(+)-MK 801 MALEATE 10MG

Catalog Number: (100505-630)
Supplier: R&D Systems
Description: (+)-MK 801 MALEATE 10MG
Image Unavailable-100507-014

MK 212 HYDROCHLORIDE 50MG

Catalog Number: (100507-014)
Supplier: R&D Systems
Description: MK 212 HYDROCHLORIDE 50MG
Image Unavailable-100506-176

MK 212 HYDROCHLORIDE 10MG

Catalog Number: (100506-176)
Supplier: R&D Systems
Description: MK 212 HYDROCHLORIDE 10MG
Image Unavailable-102875-966

MK 1903 (10 MG)

Catalog Number: (102875-966)
Supplier: R&D Systems
Description: MK 1903 (10 MG)
Image Unavailable-100507-026

(-)-MK 801 MALEATE 50MG

Catalog Number: (100507-026)
Supplier: R&D Systems
Description: (-)-MK 801 MALEATE 50MG
Image Unavailable-102658-478

MK 801 3H 250 UCI

Catalog Number: (102658-478)
Supplier: American Radiolabeled Chemicals
Description: MK 801 3H 250 UCI
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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