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Image Unavailable-10391-098

Anti-PFKL Rabbit Polyclonal Antibody

Catalog Number: (10391-098)
Supplier: Bioss
Description: PFKL is the major form in liver and kidney while only M type PFK isozyme is expressed in mature muscle; therefore, muscle contains only homotetramers of M subunits. Erythrocytes contain both L and M subunits, and these randomly tetramerize to form M4, L4, and 3 additional hybrid forms of the holoenzyme.
Product Image-10071-478

Anti-IGF1R Rabbit Polyclonal Antibody

Catalog Number: (10071-478)
Supplier: Prosci
Description: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
Product Image-RL600-106-096

Anti-Fluorescein Goat Polyclonal Antibody (Biotin)

Catalog Number: (RL600-106-096)
Supplier: Rockland Immunochemical
Description: Anti-Fluorescein Antibody Biotin Conjugated is suitable for immunoblotting, ELISA, in situ hybridization, immunochemistry, immunomicroscopy as well as other antibody based assays using streptavidin or avidin conjugates requiring lot-to-lot consistency.

SDS


Product Image-10122-694

EXP® Nano Fittings for 6-40 Ports and ¹/₃₂" Stainless Steel Tubing

Supplier: Optimize
Description: The EXP Fitting System is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between ¹/₃₂" or ¹/₁₆" tubing and any 6-32, 6-40 or 10-32 port.

Product Image-10813-996

Anti-INSR Rabbit Polyclonal Antibody

Catalog Number: (10813-996)
Supplier: Prosci
Description: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. Ref.40 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.46 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Product Image-77975-309

Iscove's Modified Dulbecco's Medium

Catalog Number: (77975-309)
Supplier: FUJIFILM IRVINE SCIENTIFIC INC.
Description: Iscove's Modified Dulbecco's Medium (IMDM) is a modification of Dulbecco's Basal Medium Eagle (BME) that uses high glucose and pyruvate, additional amino acids, 25 mM HEPES, selenium, and other components. IMDM is designed for serum-free growth of hemopoietic cells in culture and supports the growth of lymphocytes and a variety of other hybrid cells.

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Image Unavailable-10388-128

Anti-Radixin Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10388-128)
Supplier: Bioss
Description: Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Image Unavailable-77440-422

Anti-SNAI1, SNAI2, SNAI3 Rabbit Polyclonal Antibody

Catalog Number: (77440-422)
Supplier: Bioss
Description: The zinc finger transcription factor 'SNAIL' was first identified in Drosophila and, along with 'twist', a basic helix-loop-helix transcription factor, is indispensable for mesoderm formation. SNAIL is a repressor of mouse E-cadherin transcription, with expression of SNAIL inversely correlated with expression of E-cadherin. Abnormal expression of SNAIL could underlie the tumorigenic conversion of epithelia associated with loss of E-cadherin expression through screening mouse and human cell lines and by in situ hybridization of primary human tumors undergoing malignant progression.
Product Image-PAG3041

DNA (Deoxyribonucleic acid)

Catalog Number: (PAG3041)
Supplier: Promega Corporation
Description: Human mixed male and female Genomic DNA is purified and stored in 10mM Tris-HCl (pH 8.0), 1mM EDTA >90% of the DNA is longer than 50kb in size as measured by pulsed-field gel electrophoresis. The DNA is suitable for Southern blot hybridizations, genomic analysis (including PCR) and genomic library construction. Human Genomic DNA comes from multiple anonymous donors.

SDS Certificates


Product Image-10392-968

Anti-ECT2 Rabbit Polyclonal Antibody

Catalog Number: (10392-968)
Supplier: Bioss
Description: The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. [provided by RefSeq].
Product Image-10836-616

Pilot® Dr. Grip® FullBlack Advanced Ink Retractable Ball Point Pen

Catalog Number: (10836-616)
Supplier: Janitorial Supplies
Description: Dr. Grip® is the first truly ergonomic ultra-smooth writing instrument commended for Ease-of-Use by the Arthritis Foundation®.
Image Unavailable-103271-024

Anti-FBN2 Rabbit Polyclonal Antibody

Catalog Number: (103271-024)
Supplier: Novus Biologicals
Description: The Fibrillin 2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to Fibrillin 2. This antibody reacts with human. The Fibrillin 2 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, In-situ Hybridization.
Image Unavailable-76002-882

Anti-Digoxigenin, Digoxin Sheep Polyclonal Antibody

Catalog Number: (76002-882)
Supplier: Enzo Life Sciences
Description: Recommended Applications: ELISA, WB, TUNEL, ISH (in situ hybridization)

Species reactivity: Species independent
Product Image-76307-596

Rebel Hybrid Microscope, Upright and Inverted, Discover Echo

Supplier: DISCOVER ECHO INC.
Description: Rebel is designed around the user to challenge the status quo. Designed from the ground up to improve microscopy.

Product Image-76531-224

Cole-Parmer Stuart Hybrigene and Hybridizer Incubators, Antylia Scientific

Supplier: Antyila Scientific
Description: Use and recover volumes as low as 5 ml, ensuring preservation of precious samples.

Product Image-10101-176

Anti-CHRFAM7A Rabbit Polyclonal Antibody

Catalog Number: (10101-176)
Supplier: Prosci
Description: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7 is located on chromosome 15 in a region associated with several neuropsychiatric disorders. CHRFAM7A is is a hybrid between CHRNA7 and FAM7A.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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