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Product Image-MSPP-PAA848MU1

Anti-PYGM Rabbit Polyclonal Antibody

Catalog Number: (MSPP-PAA848MU1)
Supplier: CLOUD-CLONE CORP MS
Description: Polyclonal antibody to Glycogen Phosphorylase, Muscle (PYGM), derived from recombinant PYGM(Arg11~Gly187), is reactive with Mouse/Human/Rat.

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Image Unavailable-10295-026

Anti-GAA Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10295-026)
Supplier: Bioss
Description: This gene encodes acid alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. Different forms of acid alpha-glucosidase are obtained by proteolytic processing. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Image Unavailable-10295-034

Anti-GAA Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10295-034)
Supplier: Bioss
Description: This gene encodes acid alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. Different forms of acid alpha-glucosidase are obtained by proteolytic processing. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Image Unavailable-10355-646

Anti-GSK3B Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10355-646)
Supplier: Bioss
Description: Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating Glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation.
Image Unavailable-10355-644

Anti-GSK3B Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10355-644)
Supplier: Bioss
Description: Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating Glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation.
Product Image-10070-270

Anti-AKT1 Rabbit Polyclonal Antibody

Catalog Number: (10070-270)
Supplier: Prosci
Description: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.
Image Unavailable-10298-190

Anti-GYG1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10298-190)
Supplier: Bioss
Description: Glycogen synthesis is initiated by the autoglucosylation of Glycogenin-1. Specifically, Glycogenin-1 glucosylates itself to begin the synthesis of Glycogen in mammalian skeletal muscle. It acts as the primer to which further glucose monomers may be added. All of the Glycogenin-1 molecules contain at least one glucosyl residue before autoglucosylation begins. The first step of the Glycogen synthesis occurs when a glucose molecule from UDP-glucose binds to the hydroxyl group of Tyr 194 on the Glycogenin-1 molecule. Using its glucosyltransferase activity, Glycogenin-1 adds more glucoses, each one coming from UDP-glucose. The glycosylation process reaches a plateau when five new glucose residues have been added, at which point Glycogen synthase (GS) takes over and further elongates the chain. Glycogenin-1 remains covalently attached to the reducing end of the Glycogen molecule.
Image Unavailable-76082-728

Anti-PDPK1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76082-728)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of Glycogen synthase and the stimulation of Glycogen synthesis. Because of the role that PDK plays in insulin-induced Glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
Image Unavailable-76085-526

Anti-GYG1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76085-526)
Supplier: Bioss
Description: This gene encodes a member of the glycogenin family. glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
Image Unavailable-10403-536

Anti-IGF1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10403-536)
Supplier: Bioss
Description: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.
Image Unavailable-103007-734

Rabbit CK1 Peptide Substrate

Catalog Number: (103007-734)
Supplier: Anaspec Inc
Description: This peptide sequence is based on rabbit muscle glycogen synthase with Ser7 phosphorylated. It is a peptide substrate for Casein Kinase I (CK1). CK1 phosphorylates Ser10. Ser7 is phosphorylated by PKA in vivo.
Sequence:KRRRAL-pS-VASLPGL
MW:1603.9 Da
% peak area by HPLC:95
Storage condition:-20° C
Image Unavailable-10229-058

Anti-IGF1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10229-058)
Supplier: Bioss
Description: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.
Product Image-10070-174

Anti-GSK3A Rabbit Polyclonal Antibody

Catalog Number: (10070-174)
Supplier: Prosci
Description: Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.
Image Unavailable-AAA13687-14

ω,4-Dibromoacetophenone 98+%

Supplier: Thermo Scientific Chemicals
Description: ω,4-Dibromoacetophenone 98+%

SDS Certificates

Image Unavailable-10398-386

Anti-GSK3A Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10398-386)
Supplier: Bioss
Description: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Image Unavailable-102516-154

Bisindolylmaleimide I hydrochloride 98

Supplier: Adipogen
Description: Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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